Immunology Journal Club Papers

November 19, 2024

Wenyi Li (Feske Lab)

Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Parvaneh N, Alipour-Olyei N, Carapito R, Xu Q, Preite S, Beck DB, Chae JJ, Nehrebecky M, Ombrello AK, Hoffmann P, Romeo T, Deuitch NT, Matthíasardóttir B, Mullikin J, Komarow H, Stoddard J, Niemela J, Dobbs K, Sweeney CL, Anderton H, Lawlor KE, Yoshitomi H, Yang D, Boehm M, Davis J, Mudd P, Randazzo D, Tsai WL, Gadina M, Kaplan MJ, Toguchida J, Mayer CT, Rosenzweig SD, Notarangelo LD, Iwai K, Silke J, Schwartzberg PL, Boisson B, Casanova JL, Bahram S, Rao AP, Peltzer N, Walczak H, Lalaoui N, Aksentijevich I, Kastner DL. Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nat Immunol. 2024 May;25(5):764-777. doi: 10.1038/s41590-024-01817-w. Epub 2024 Apr 12. PMID: 38609546.

Velmurugu Yogambigai (Krogsgaard Lab)

Zhong Y, Kang AYH, Tay CJX, Li HE, Elyana N, Tan CW, Yap WC, Lim JME, Le Bert N, Chan KR, Ong EZ, Low JG, Shek LP, Tham EH, Ooi EE. Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children. Nat Med. 2024 May;30(5):1373-1383. doi: 10.1038/s41591-024-02962-3. Epub 2024 Apr 30. Erratum in: Nat Med. 2024 Jul;30(7):2093. doi: 10.1038/s41591-024-03107-2. PMID: 38689059; PMCID: PMC11164684.

November 12, 2024

Lucile Noyer (Feske Lab)

Soll D, Chu CF, Sun S, Lutz V, Arunkumar M, Gachechiladze M, Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil MA, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE. Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. Nat Immunol. 2024 Oct;25(10):1830-1844. doi: 10.1038/s41590-024-01918-6. Epub 2024 Aug 28. PMID: 39198632; PMCID: PMC11436365.

Scirgolea C, Sottile R, De Luca M, Susana A, Carnevale S, Puccio S, Ferrari V, Lise V, Contarini G, Scarpa A, Scamardella E, Feno S, Camisaschi C, De Simone G, Basso G, Giuliano D, Mazza EMC, Gattinoni L, Roychoudhuri R, Voulaz E, Di Mitri D, Simonelli M, Losurdo A, Pozzi D, Tsui C, Kallies A, Timo S, Martano G, Barberis E, Manfredi M, Rescigno M, Jaillon S, Lugli E. NaCl enhances CD8+ T cell effector functions in cancer immunotherapy. Nat Immunol. 2024 Oct;25(10):1845-1857. doi: 10.1038/s41590-024-01923-9. Epub 2024 Aug 28. PMID: 39198631.

November 5, 2024

Alan Varghese (Littman and Nudler Labs)

Kim MW, Gao W, Lichti CF, Gu X, Dykstra T, Cao J, Smirnov I, Boskovic P, Kleverov D, Salvador AFM, Drieu A, Kim K, Blackburn S, Crewe C, Artyomov MN, Unanue ER, Kipnis J. Endogenous self-peptides guard immune privilege of the central nervous system. Nature. 2024 Oct 30. doi: 10.1038/s41586-024-08279-y. Epub ahead of print. PMID: 39476864.

October 29, 2024

Yuelin Song (Littman Lab)

Amrute JM, Luo X, Penna V, Yang S, Yamawaki T, Hayat S, Bredemeyer A, Jung IH, Kadyrov FF, Heo GS, Venkatesan R, Shi SY, Parvathaneni A, Koenig AL, Kuppe C, Baker C, Luehmann H, Jones C, Kopecky B, Zeng X, Bleckwehl T, Ma P, Lee P, Terada Y, Fu A, Furtado M, Kreisel D, Kovacs A, Stitziel NO, Jackson S, Li CM, Liu Y, Rosenthal NA, Kramann R, Ason B, Lavine KJ. Targeting immune-fibroblast cell communication in heart failure. Nature. 2024 Oct 23. doi: 10.1038/s41586-024-08008-5. Epub ahead of print. PMID: 39443792.

Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, Gardner Z, Li L, Costa MW, Jain R, Charo I, Combes AJ, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. Chromatin remodelling drives immune cell-fibroblast communication in heart failure. Nature. 2024 Oct 23. doi: 10.1038/s41586-024-08085-6. Epub ahead of print. PMID: 39443808.

October 22, 2024

Joe Pucella (Axelrad Lab)

El Morr Y, Fürstenheim M, Mestdagh M, Franciszkiewicz K, Salou M, Morvan C, Dupré T, Vorobev A, Jneid B, Premel V, Darbois A, Perrin L, Mondot S, Colombeau L, Bugaut H, du Halgouet A, Richon S, Procopio E, Maurin M, Philippe C, Rodriguez R, Lantz O, Legoux F. MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis. Sci Immunol. 2024 Jun 21;9(96):eadi8954. doi: 10.1126/sciimmunol.adi8954. Epub 2024 Jun 21. PMID: 38905325; PMCID: PMC7616241.

Francis Chen (Littman Lab)

Hou Y, Sun L, LaFleur MW, Huang L, Lambden C, Thakore PI, Geiger-Schuller K, Kimura K, Yan L, Zang Y, Tang R, Shi J, Barilla R, Deng L, Subramanian A, Wallrapp A, Choi HS, Kye YC, Ashenberg O, Schiebinger G, Doench JG, Chiu IM, Regev A, Sharpe AH, Kuchroo VK. Neuropeptide signalling orchestrates T cell differentiation. Nature. 2024 Oct 16. doi: 10.1038/s41586-024-08049-w. Epub ahead of print. PMID: 39415015.

October 15, 2024

Pei-Feng Hsu (Reizis Lab)

Di Luccia B, Molgora M, Khantakova D, Jaeger N, Chang HW, Czepielewski RS, Helmink BA, Onufer EJ, Fachi JL, Bhattarai B, Trsan T, Rodrigues PF, Hou J, Bando JK, da Silva CS, Cella M, Gilfillan S, Schreiber RD, Gordon JI, Colonna M. TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy. Sci Immunol. 2024 May 17;9(95):eadi5374. doi: 10.1126/sciimmunol.adi5374. Epub 2024 May 17. PMID: 38758808; PMCID: PMC11299520.

October 8, 2024

Areli Lopez Bujanda (Littman Lab)

Chang H, Perkins MH, Novaes LS, Qian F, Zhang T, Neckel PH, Scherer S, Ley RE, Han W, de Araujo IE. Stress-sensitive neural circuits change the gut microbiome via duodenal glands. Cell. 2024 Sep 19;187(19):5393-5412.e30. doi: 10.1016/j.cell.2024.07.019. Epub 2024 Aug 8. PMID: 39121857; PMCID: PMC11425084.

October 1, 2024

Boris Reizis

Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogoh A, Sakaguchi S, Ogawa Y, Arase H. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell. 2024 Sep 11:S0092-8674(24)00913-9. doi: 10.1016/j.cell.2024.08.025. Epub ahead of print. PMID: 39276775.

Juan Lafaille

Anfray A, Schaeffer S, Hattori Y, Santisteban MM, Casey N, Wang G, Strickland M, Zhou P, Holtzman DM, Anrather J, Park L, Iadecola C. A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nat Neurosci. 2024 Sep 18. doi: 10.1038/s41593-024-01757-6. Epub ahead of print. PMID: 39294490.

September 24, 2024

Taejin Yun (Reizis Lab)

Appios A, Davies J, Sirvent S, Henderson S, Trzebanski S, Schroth J, Law ML, Carvalho IB, Pinto MM, Carvalho C, Kan HY, Lovlekar S, Major C, Vallejo A, Hall NJ, Ardern-Jones M, Liu Z, Ginhoux F, Henson SM, Gentek R, Emmerson E, Jung S, Polak ME, Bennett CL. Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity. Sci Immunol. 2024 Sep 6;9(99):eadp0344. doi: 10.1126/sciimmunol.adp0344. Epub 2024 Sep 6. PMID: 39241057.

Hailin Tu (Littman Lab)

Ocón B, Xiang M, Bi Y, Tan S, Brulois K, Ayesha A, Kunte M, Zhou C, LaJevic M, Lazarus N, Mengoni F, Sharma T, Montgomery S, Hooper JE, Huang M, Handel T, Dawson JRD, Kufareva I, Zabel BA, Pan J, Butcher EC. A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS. Nature. 2024 Sep 18. doi: 10.1038/s41586-024-08043-2. Epub ahead of print. PMID: 39293486.

September 17, 2024

Liuhui Fu (Littman Lab)

Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W. A brain-to-gut signal controls intestinal fat absorption. Nature. 2024 Sep 11. doi: 10.1038/s41586-024-07929-5. Epub ahead of print. PMID: 39261733.

September 10, 2024

Apoorvi Tyagi (Krogsgaard Lab)

Lauss M, Phung B, Borch TH, Harbst K, Kaminska K, Ebbesson A, Hedenfalk I, Yuan J, Nielsen K, Ingvar C, Carneiro A, Isaksson K, Pietras K, Svane IM, Donia M, Jönsson G. Molecular patterns of resistance to immune checkpoint blockade in melanoma. Nat Commun. 2024 Apr 9;15(1):3075. doi: 10.1038/s41467-024-47425-y. PMID: 38594286; PMCID: PMC11004175.

Luan Firmino Cruz (Nowosad Lab)

Wakamatsu E, Machiyama H, Toyota H, Takeuchi A, Hashimoto R, Kozono H, Yokosuka T. Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II. Cell Rep. 2024 Aug 21:114655. doi: 10.1016/j.celrep.2024.114655. Epub ahead of print. PMID: 39191259.

September 3, 2024

Tenny Mudianto (Lund Lab)

de Jong MME, Fokkema C, Papazian N, Czeti Á, Appelman MK, Vermeulen M, van Heusden T, Hoogenboezem RM, van Beek G, Tahri S, Sanders MA, van de Woestijne PC, Gay F, Moreau P, Büttner-Herold M, Bruns H, van Duin M, Broijl A, Sonneveld P, Cupedo T. An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma. Nat Immunol. 2024 May;25(5):820-833. doi: 10.1038/s41590-024-01808-x. Epub 2024 Apr 10. PMID: 38600356.

Li Zhong (Feske Lab)

Woo MS, Mayer C, Binkle-Ladisch L, Sonner JK, Rosenkranz SC, Shaposhnykov A, Rothammer N, Tsvilovskyy V, Lorenz SM, Raich L, Bal LC, Vieira V, Wagner I, Bauer S, Glatzel M, Conrad M, Merkler D, Freichel M, Friese MA. STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024 Jul 25;187(15):4043-4060.e30. doi: 10.1016/j.cell.2024.05.031. Epub 2024 Jun 14. PMID: 38878778.

August 27, 2024

Katie Ventre (Lund Lab)

Zhao R, Zhang J, Ma J, Qu Y, Yang Z, Yin Z, Li F, Dong Z, Sun Q, Zhu S, Chen ZJ, Gao D. cGAS-activated endothelial cell-T cell cross-talk initiates tertiary lymphoid structure formation. Sci Immunol. 2024 Aug 2;9(98):eadk2612. doi: 10.1126/sciimmunol.adk2612. Epub 2024 Aug 2. PMID: 39093956.

Nick Adams (Reizis Lab)

Alraies Z, Rivera CA, Delgado M-G, Sanséau D, Maurin M, Amadio R, Maria Piperno G, Dunsmore G, Yatim A, Lacerda Mariano L, Kniazeva A, Calmettes V, Sáez PJ, Williart A, Popard H, Gratia M, Lamiable O, Moreau A, Fusilier Z, Crestey L, Albaud B, Legoix P, Dejean AS, Le Dorze A-L, Nakano H, Cook DN, Lawrence T, Manel N, Benvenuti F, Ginhoux F, Moreau HD, Nader GPF, Piel M, Lennon-Duménil A-M. Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes. Nat. Immunol. 2024 Jul;25(7):1193-1206. doi: 10.1038/s41590-024-01856-3. Epub 2024 Jun 4. PMID: 38834865. MPCID: PMC11224020.

August 20, 2024

Natália Pinheiro (Lafaille Lab)

Fesneau O, Thevin V, Pinet V, Goldsmith C, Vieille B, M'Homa Soudja S, Lattanzio R, Hahne M, Dardalhon V, Hernandez-Vargas H, Benech N, Marie JC. An intestinal TH17 cell-derived subset can initiate cancer. Nat Immunol. 2024 Jul 26. doi: 10.1038/s41590-024-01909-7. Epub ahead of print. PMID: 39060651.

August 13, 2024

Ethan Tardio (Krogsgaard Lab)

van Gulijk M, van Krimpen A, Schetters S, Eterman M, van Elsas M, Mankor J, Klaase L, de Bruijn M, van Nimwegen M, van Tienhoven T, van Ijcken W, Boon L, van der Schoot J, Verdoes M, Scheeren F, van der Burg SH, Lambrecht BN, Stadhouders R, Dammeijer F, Aerts J, van Hall T. PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance. Sci Immunol. 2023 May 19;8(83):eabn6173. doi: 10.1126/sciimmunol.abn6173. Epub 2023 May 19. PMID: 37205768.

July 30, 2024

Jian Guan (Littman Lab)

Giampazolias E, Pereira da Costa M, Lam KC, Lim KHJ, Cardoso A, Piot C, Chakravarty P, Blasche S, Patel S, Biram A, Castro-Dopico T, Buck MD, Rodrigues RR, Poulsen GJ, Palma-Duran SA, Rogers NC, Koufaki MA, Minutti CM, Wang P, Vdovin A, Frederico B, Childs E, Lee S, Simpson B, Iseppon A, Omenetti S, Kelly G, Goldstone R, Nye E, Suárez-Bonnet A, Priestnall SL, MacRae JI, Zelenay S, Patil KR, Litchfield K, Lee JC, Jess T, Goldszmid RS, Reis E Sousa C. Vitamin D regulates microbiome-dependent cancer immunity. Science. 2024 Apr 26;384(6694):428-437. doi: 10.1126/science.adh7954. Epub 2024 Apr 25. PMID: 38662827; PMCID: PMC7615937.

July 23, 2024

Rabi Upadhyay (Littman Lab)

Widjaja AA, Lim WW, Viswanathan S, Chothani S, Corden B, Dasan CM, Goh JWT, Lim R, Singh BK, Tan J, Pua CJ, Lim SY, Adami E, Schafer S, George BL, Sweeney M, Xie C, Tripathi M, Sims NA, Hübner N, Petretto E, Withers DJ, Ho L, Gil J, Carling D, Cook SA. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. 2024 Jul 17. doi: 10.1038/s41586-024-07701-9. Epub ahead of print. PMID: 39020175.

July 16, 2024

Alan Varghese (Littman and Nudler Labs)

Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA. A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection. Nature. 2024 Jul 10. doi: 10.1038/s41586-024-07630-7. Epub ahead of print. PMID: 38987588.

July 9, 2024

Yuelin Song (Littman Lab)

Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell. 2024 Jun 28:S0092-8674(24)00652-4. doi: 10.1016/j.cell.2024.06.012. Epub ahead of print. PMID: 38968937.

July 2, 2024

Francis Chen (Littman Lab)

Bader JE, Wolf MM, Lupica-Tondo GL, Madden MZ, Reinfeld BI, Arner EN, Hathaway ES, Steiner KK, Needle GA, Hatem Z, Landis MD, Faneuff EE, Blackman A, Wolf EM, Cottam MA, Ye X, Bates ME, Smart K, Wang W, Pinheiro LV, Christofides A, Smith D, Boussiotis VA, Haake SM, Beckermann KE, Wellen KE, Reinhart-King CA, Serezani CH, Lee CH, Aubrey C, Chen H, Rathmell WK, Hasty AH, Rathmell JC. Obesity induces PD-1 on macrophages to suppress anti-tumour immunity. Nature. 2024 Jun;630(8018):968-975. doi: 10.1038/s41586-024-07529-3. Epub 2024 Jun 12. PMID: 38867043.

Susan Schwab

Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Shen Z, Wang Y, Wang S, Brosseau JP, Wang F, Liu G, Quan Y, Xu J. ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion. Cell. 2024 Apr 25;187(9):2305-2323.e33. doi: 10.1016/j.cell.2024.03.019. Epub 2024 Apr 12. PMID: 38614099.

June 25, 2024

Pei-Feng Hsu (Reizis Lab)

Trzebanski S, Kim JS, Larossi N, Raanan A, Kancheva D, Bastos J, Haddad M, Solomon A, Sivan E, Aizik D, Kralova JS, Gross-Vered M, Boura-Halfon S, Lapidot T, Alon R, Movahedi K, Jung S. Classical monocyte ontogeny dictates their functions and fates as tissue macrophages. Immunity. 2024 Jun 11;57(6):1225-1242.e6. doi: 10.1016/j.immuni.2024.04.019. Epub 2024 May 14. PMID: 38749446.

Filio Karakousi (Lund Lab)

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors. Cell. 2024 Jun 9:S0092-8674(24)00535-X. doi: 10.1016/j.cell.2024.05.026. Epub ahead of print. PMID: 38870946.

June 18, 2024

Sally Kikvadze (Krogsgaard Lab)

Xin W, Huang B, Chi X, Liu Y, Xu M, Zhang Y, Li X, Su Q, Zhou Q. Structures of human γδ T cell receptor-CD3 complex. Nature. 2024 Jun;630(8015):222-229. doi: 10.1038/s41586-024-07439-4. Epub 2024 Apr 24. PMID: 38657677; PMCID: PMC11153141.

June 11, 2024

Juan Lafaille

De Leo A, Ugolini A, Yu X, Scirocchi F, Scocozza D, Peixoto B, Pace A, D'Angelo L, Liu JKC, Etame AB, Rughetti A, Nuti M, Santoro A, Vogelbaum MA, Conejo-Garcia JR, Rodriguez PC, Veglia F. Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma. Immunity. 2024 May 14;57(5):1105-1123.e8. doi: 10.1016/j.immuni.2024.04.006. Epub 2024 May 3. PMID: 38703775; PMCID: PMC11114377.

Areli Lopez Bujanda (Littman Lab)

Wu M, Song G, Li J, Song Z, Zhao B, Liang L, Li W, Hu H, Tu H, Li S, Li P, Zhang B, Wang W, Zhang Y, Zhang W, Zheng W, Wang J, Wen Y, Wang K, Li A, Zhou T, Zhang Y, Li H. Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity. Cell. 2024 Jun 6;187(12):2935-2951.e19. doi: 10.1016/j.cell.2024.04.027. Epub 2024 May 20. PMID: 38772371.

June 4, 2024

Hailin Tu (Littman Lab)

Yang L, He H, Guo XK, Wang J, Wang W, Li D, Liang S, Shao F, Liu W, Hu X. Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity. Immunity. 2024 May 14;57(5):1056-1070.e5. doi: 10.1016/j.immuni.2024.03.017. Epub 2024 Apr 12. PMID: 38614091.

May 21, 2024

Liwei Wang (Feske Lab)

Huang S, Dong W, Lin X, Xu K, Li K, Xiong S, Wang Z, Nie X, Bian JS. Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. Immunity. 2024 Mar 12;57(3):495-512.e11. doi: 10.1016/j.immuni.2024.01.018. Epub 2024 Feb 22. PMID: 38395698.

May 14, 2024

Li Zhong (Feske Lab)

Jovasevic V, Wood EM, Cicvaric A, Zhang H, Petrovic Z, Carboncino A, Parker KK, Bassett TE, Moltesen M, Yamawaki N, Login H, Kalucka J, Sananbenesi F, Zhang X, Fischer A, Radulovic J. Formation of memory assemblies through the DNA-sensing TLR9 pathway. Nature. 2024 Apr;628(8006):145-153. doi: 10.1038/s41586-024-07220-7. Epub 2024 Mar 27. PMID: 38538785; PMCID: PMC10990941.

Apoorvi Tyagi (Krogsgaard Lab)

Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F. Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer. Nat Commun. 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380; PMCID: PMC10984943.

May 7, 2024

Nick Adams (Reizis Lab)

Patta I, Zand M, Lee L, Mishra S, Bortnick A, Lu H, Prusty A, McArdle S, Mikulski Z, Wang HY, Cheng CS, Fisch KM, Hu M, Murre C. Nuclear morphology is shaped by loop-extrusion programs. Nature. 2024 Mar;627(8002):196-203. doi: 10.1038/s41586-024-07086-9. Epub 2024 Feb 14. PMID: 38355805; PMCID: PMC11052650.

Tenny Mudianto (Lund Lab)

Manakkat Vijay GK, Zhou M, Thakkar K, Rothrauff A, Chawla AS, Chen D, Lau LC, Gerges PH, Chetal K, Chhibbar P, Fan J, Das J, Joglekar A, Borghesi L, Salomonis N, Xu H, Singh H. Temporal dynamics and genomic programming of plasma cell fates. Nat Immunol. 2024 May 2. doi: 10.1038/s41590-024-01831-y. Epub ahead of print. PMID: 38698087.

April 30, 2024

Annesa Das (Reizis Lab)

Joshi G, Décembre E, Brocard J, Montpellier C, Ferrié M, Allatif O, Mehnert A-K, Pons J, Galiana D, Thi VLD, Jouvenet N, Cocquerel L, Dreux M (2024) Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein. bioRxiv 2024.2004.2012.589258.

Laetitia Weinhard (Littman Lab)

Smyth LCD, Xu D, Okar SV, Dykstra T, Rustenhoven J, Papadopoulos Z, Bhasiin K, Kim MW, Drieu A, Mamuladze T, Blackburn S, Gu X, Gaitán MI, Nair G, Storck SE, Du S, White MA, Bayguinov P, Smirnov I, Dikranian K, Reich DS, Kipnis J. Identification of direct connections between the dura and the brain. Nature. 2024 Mar;627(8002):165-173. doi: 10.1038/s41586-023-06993-7. Epub 2024 Feb 7. PMID: 38326613.

April 23, 2024

Natalia Pinheiro (Lafaille Lab)

Gu Y, Bartolomé-Casado R, Xu C, Bertocchi A, Janney A, Heuberger C, Pearson CF, Teichmann SA, Thornton EE, Powrie F. Immune microniches shape intestinal Treg function. Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07251-0. Epub ahead of print. PMID: 38570678.

Katie Ventre (Lund Lab)

De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG. Mast cells help organize the Peyer's patch niche for induction of IgA responses. Sci Immunol. 2024 Mar;9(93):eadj7363. doi: 10.1126/sciimmunol.adj7363. Epub 2024 Mar 1. PMID: 38427721; PMCID: PMC11008922.

April 16, 2024

Velmurugu Yogambigai (Krogsgaard Lab)

Velasco Cárdenas RM, Brandl SM, Meléndez AV, Schlaak AE, Buschky A, Peters T, Beier F, Serrels B, Taromi S, Raute K, Hauri S, Gstaiger M, Lassmann S, Huppa JB, Boerries M, Andrieux G, Bengsch B, Schamel WW, Minguet S. Harnessing CD3 diversity to optimize CAR T cells. Nat Immunol. 2023 Dec;24(12):2135-2149. doi: 10.1038/s41590-023-01658-z. Epub 2023 Nov 6. PMID: 37932456; PMCID: PMC10681901.

Jasper Du (Wang Lab)

Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H. ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature. 2024 Apr 10. doi: 10.1038/s41586-024-07373-5. Epub ahead of print. PMID: 38599239.

April 9, 2024

Carla Nowosad

Sonnert ND, Rosen CE, Ghazi AR, Franzosa EA, Duncan-Lowey B, González-Hernández JA, Huck JD, Yang Y, Dai Y, Rice TA, Nguyen MT, Song D, Cao Y, Martin AL, Bielecka AA, Fischer S, Guan C, Oh J, Huttenhower C, Ring AM, Palm NW. A host-microbiota interactome reveals extensive transkingdom connectivity. Nature. 2024 Apr;628(8006):171-179. doi: 10.1038/s41586-024-07162-0. Epub 2024 Mar 20. PMID: 38509360.

Wenyi Li (Feske Lab)

Ross JB, Myers LM, Noh JJ, Collins MM, Carmody AB, Messer RJ, Dhuey E, Hasenkrug KJ, Weissman IL. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature. 2024 Apr;628(8006):162-170. doi: 10.1038/s41586-024-07238-x. Epub 2024 Mar 27. PMID: 38538791.

April 2, 2024

Rabi Upadhyay (Littman Lab)

Jia D, Wang Q, Qi Y, Jiang Y, He J, Lin Y, Sun Y, Xu J, Chen W, Fan L, Yan R, Zhang W, Ren G, Xu C, Ge Q, Wang L, Liu W, Xu F, Wu P, Wang Y, Chen S, Wang L. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell. 2024 Mar 28;187(7):1651-1665.e21. doi: 10.1016/j.cell.2024.02.022. Epub 2024 Mar 14. PMID: 38490195.

March 26, 2024

Anthony Tao (Feske Lab)

Tsai YL, Arias-Badia M, Kadlecek TA, Lwin YM, Srinath A, Shah NH, Wang ZE, Barber D, Kuriyan J, Fong L, Weiss A. TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments. Immunity. 2023 Dec 12;56(12):2682-2698.e9. doi: 10.1016/j.immuni.2023.11.010. PMID: 38091950; PMCID: PMC10785950.

Alan Varghese (Littman and Nudler Labs)

Torres SV, Man K, Elmzzahi T, Malko D, Chisanga D, Liao Y, Prout M, Abbott CA, Tang A, Wu J, Becker M, Mason T, Haynes V, Tsui C, Shakiba MH, Hamada D, Britt K, Groom JR, McColl SR, Shi W, Watt MJ, Le Gros G, Pal B, Beyer M, Vasanthakumar A, Kallies A. Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism. Nat Immunol. 2024 Mar;25(3):496-511. doi: 10.1038/s41590-024-01753-9. Epub 2024 Feb 14. PMID: 38356058.

March 19, 2024

Kai Mesa (Littman Lab)

Tufan T, Comertpay G, Villani A, Nelson GM, Terekhova M, Kelley S, Zakharov P, Ellison RM, Shpynov O, Raymond M, Sun J, Chen Y, Bockelmann E, Stremska M, Peterson LW, Boeckaerts L, Goldman SR, Etchegaray JI, Artyomov MN, Peri F, Ravichandran KS. Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07172-y. Epub ahead of print. PMID: 38480883.

March 12, 2024

Yuelin Song (Littman Lab)

Nakandakari-Higa S, Walker S, Canesso MCC, van der Heide V, Chudnovskiy A, Kim DY, Jacobsen JT, Parsa R, Bilanovic J, Parigi SM, Fiedorczuk K, Fuchs E, Bilate AM, Pasqual G, Mucida D, Kamphorst AO, Pritykin Y, Victora GD. Universal recording of immune cell interactions in vivo. Nature. 2024 Mar 6. doi: 10.1038/s41586-024-07134-4. Epub ahead of print. PMID: 38448581.

Susan Schwab

Badr ME, Zhang Z, Tai X, Singer A. CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus. Science. 2023 Nov 3;382(6670):534-541. doi: 10.1126/science.adh4124. Epub 2023 Nov 2. PMID: 37917689.

March 5, 2024

Filio Karakousi (Lund Lab)

Yin X, Zhang S, Lee JH, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo LH, Poulet M, Fischer S, Zhou T, Mohammed FS, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas JL, Saltzman WM, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Compartmentalized ocular lymphatic system mediates eye-brain immunity. Nature. 2024 Feb 28. doi: 10.1038/s41586-024-07130-8. Epub ahead of print. PMID: 38418880.

Francis Chen (Littman Lab)

Minutti CM, Piot C, Pereira da Costa M, Chakravarty P, Rogers N, Huerga Encabo H, Cardoso A, Loong J, Bessou G, Mionnet C, Langhorne J, Bonnet D, Dalod M, Tomasello E, Reis E Sousa C. Distinct ontogenetic lineages dictate cDC2 heterogeneity. Nat Immunol. 2024 Feb 13. doi: 10.1038/s41590-024-01745-9. Epub ahead of print. PMID: 38351322.

February 20, 2024

Sally Kikvadze (Krogsgaard Lab)

Gaud G, Achar S, Bourassa FXP, Davies J, Hatzihristidis T, Choi S, Kondo T, Gossa S, Lee J, Juneau P, Taylor N, Hinrichs CS, McGavern DB, François P, Altan-Bonnet G, Love PE. CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. Nat Immunol. 2023 Dec;24(12):2121-2134. doi: 10.1038/s41590-023-01663-2. Epub 2023 Nov 9. Erratum in: Nat Immunol. 2023 Dec 6;: PMID: 37945821.

Pei-Feng Hsu (Reizis Lab)

McKendrick JG, Jones GR, Elder SS, Watson E, T'Jonck W, Mercer E, Magalhaes MS, Rocchi C, Hegarty LM, Johnson AL, Schneider C, Becher B, Pridans C, Mabbott N, Liu Z, Ginhoux F, Bajenoff M, Gentek R, Bain CC, Emmerson E. CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury. Sci Immunol. 2023 Nov 3;8(89):eadd4374. doi: 10.1126/sciimmunol.add4374. Epub 2023 Nov 3. PMID: 37922341.

February 6, 2024

Amanda Lund

Malik A, Sharma D, Aguirre-Gamboa R, McGrath S, Zabala S, Weber C, Jabri B. Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity. Nature. 2023 Nov;623(7989):1044-1052. doi: 10.1038/s41586-023-06721-1. Epub 2023 Nov 22. PMID: 37993709.

Areli Lopez Bujanda (Littman Lab)

Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan SA, Kumar P, Hidalgo A, Wu D, Lu J. Cell surface RNAs control neutrophil recruitment. Cell. 2024 Jan 17:S0092-8674(23)01443-5. doi: 10.1016/j.cell.2023.12.033. Epub ahead of print. PMID: 38262409.

January 30, 2024

Boris Reizis

Cheong JG, Ravishankar A, Sharma S, Parkhurst CN, Grassmann SA, Wingert CK, Laurent P, Ma S, Paddock L, Miranda IC, Karakaslar EO, Nehar-Belaid D, Thibodeau A, Bale MJ, Kartha VK, Yee JK, Mays MY, Jiang C, Daman AW, Martinez de Paz A, Ahimovic D, Ramos V, Lercher A, Nielsen E, Alvarez-Mulett S, Zheng L, Earl A, Yallowitz A, Robbins L, LaFond E, Weidman KL, Racine-Brzostek S, Yang HS, Price DR, Leyre L, Rendeiro AF, Ravichandran H, Kim J, Borczuk AC, Rice CM, Jones RB, Schenck EJ, Kaner RJ, Chadburn A, Zhao Z, Pascual V, Elemento O, Schwartz RE, Buenrostro JD, Niec RE, Barrat FJ, Lief L, Sun JC, Ucar D, Josefowicz SZ. Epigenetic memory of coronavirus infection in innate immune cells and their progenitors. Cell. 2023 Aug 31;186(18):3882-3902.e24. doi: 10.1016/j.cell.2023.07.019. Epub 2023 Aug 18. PMID: 37597510; PMCID: PMC10638861.

Juan Lafaille

Banerjee G, Farmer SF, Hyare H, Jaunmuktane Z, Mead S, Ryan NS, Schott JM, Werring DJ, Rudge P, Collinge J. Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone. Nat Med (2024). https://doi.org/10.1038/s41591-023-02729-2

January 23, 2024

Taejin Yun (Reizis Lab)

Mukhopadhyay A, Tsukasaki Y, Chan WC, Le JP, Kwok ML, Zhou J, Natarajan V, Mostafazadeh N, Maienschein-Cline M, Papautsky I, Tiruppathi C, Peng Z, Rehman J, Ganesh B, Komarova Y, Malik AB. trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing. Immunity. 2024 Jan 9;57(1):52-67.e10. doi: 10.1016/j.immuni.2023.11.007. Epub 2023 Dec 12. PMID: 38091995.

Hailin Tu (Littman Lab)

Brockmann L, Tran A, Huang Y, Edwards M, Ronda C, Wang HH, Ivanov II. Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10. Immunity. 2023 Dec 12;56(12):2719-2735.e7. doi: 10.1016/j.immuni.2023.11.003. Epub 2023 Nov 30. PMID: 38039966.

January 16, 2024

Luan Firmino Cruz (Nowosad Lab)

Galván-Peña S, Zhu Y, Hanna BS, Mathis D, Benoist C. A dynamic atlas of immunocyte migration from the gut. Sci Immunol. 2024 Jan 5;9(91):eadi0672. doi: 10.1126/sciimmunol.adi0672. Epub 2024 Jan 5. PMID: 38181094.

Liuhui Fu (Littman Lab)

Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS. Sensory neurons promote immune homeostasis in the lung. Cell. 2024 Jan 4;187(1):44-61.e17. doi: 10.1016/j.cell.2023.11.027. Epub 2023 Dec 21. PMID: 38134932.

January 9, 2024

Liwei Wang (Feske Lab)

Ran L, Ye T, Erbs E, Ehl S, Spassky N, Sumara I, Zhang Z, Ricci R. KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation. Sci Immunol. 2023 Dec 22;8(90):eadf4699. doi: 10.1126/sciimmunol.adf4699. Epub 2023 Dec 22. PMID: 38134241.

Nick Adams (Reizis Lab)

Belabed, M., M. D. Park, C. M. Blouin, S. Balan, C. Y. Moon, J. Boumelha, A. Peros, R. Mattiuz, A. M. Reid, C. S. Azimi, N. M. LaMarche, L. Troncoso, A. Amabile, J. L. Berichel, S. T. Chen, C. M. Wilk, B. D. Brown, K. Radford, S. Ghosh, C. V. Rothlin, L. Yvan-Charvet, T. U. Marron, D. J. Puleston, N. Bhardwaj, C. Lamaze and M. Merad (2023). "AXL limits the mobilization of cholesterol to regulate dendritic cell maturation and the immunogenic response to cancer." bioRxiv: 2023.2012.2025.573303.

December 19, 2023

Li Zhong (Feske Lab)

Wu L, Hong X, Yang C, Yang Y, Li W, Lu L, Cai M, Cao D, Zhuang G, Deng L. Noncanonical MAVS signaling restrains dendritic cell-driven antitumor immunity by inhibiting IL-12. Sci Immunol. 2023 Dec;8(90):eadf4919. doi: 10.1126/sciimmunol.adf4919. Epub 2023 Dec 1. PMID: 38039379.

December 5, 2023

Laetitia Weinhard (Littman Lab)

Sang D, Lin K, Yang Y, Ran G, Li B, Chen C, Li Q, Ma Y, Lu L, Cui XY, Liu Z, Lv SQ, Luo M, Liu Q, Li Y, Zhang EE. Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals. Cell. 2023 Nov 14:S0092-8674(23)01176-5. doi: 10.1016/j.cell.2023.10.025. Epub ahead of print. PMID: 38016470.

Tenny Mudianto (Lund Lab)

Biswas S, Mandal G, Anadon CM, Chaurio RA, Lopez-Bailon LU, Nagy MZ, Mine JA, Hänggi K, Sprenger KB, Innamarato P, Harro CM, Powers JJ, Johnson J, Fang B, Eysha M, Nan X, Li R, Perez BA, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR. Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers. Immunity. 2023 Nov 14;56(11):2570-2583.e6. doi: 10.1016/j.immuni.2023.09.013. Epub 2023 Oct 30. PMID: 37909039.

November 28, 2023

Annesa Das (Reizis Lab)

Luo X, Lahaye X, Jaeger A, Michea-Veloso P, Manel N, Dalod M. A gene silencing pipeline to interrogate human cDC1 and pDC development and functions. bioRxiv. 2023:2023.05.16.540909. doi:10.1101/2023.05.16.540909

Taylor Heim (Lund Lab)

Jenkins MM, Bachus H, Botta D, Schultz MD, Rosenberg AF, León B, Ballesteros-Tato A. Lung dendritic cells migrate to the spleen to prime long-lived TCF1hi memory CD8+ T cell precursors after influenza infection. Sci Immunol. 2021 Sep 10;6(63):eabg6895. doi: 10.1126/sciimmunol.abg6895. Epub 2021 Sep 10. PMID: 34516781; PMCID: PMC8559272.

November 21, 2023

Payal Damani-Yokota (Khanna Lab)

Griffith JW, Faustino LD, Cottrell VI, Nepal K, Hariri LP, Chiu RS, Jones MC, Julé A, Gabay C, Luster AD. Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection. Nat Immunol. 2023 Nov 9. doi: 10.1038/s41590-023-01655-2. Epub ahead of print. PMID: 37945820.

Katie Ventre (Lund Lab)

Silva, J. G., D. Pais Ferreira, A. Dumez, T. Wyss, R. Veber, M. Danilo, D. D. Pinschewer, M. Charmoy and W. Held (2023). "Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection." Science Immunology 8(89): eadh3113.

November 14, 2023

Velmurugu Yogambigai (Krogsgaard Lab)

Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J; Penn Medicine BioBank; Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nat Immunol. 2023 Oct;24(10):1711-1724. doi: 10.1038/s41590-023-01613-y. Epub 2023 Sep 21. PMID: 37735592.

Jasper Du (Wang Lab)

Yuan L, Ma X, Yang Y, Qu Y, Li X, Zhu X, Ma W, Duan J, Xue J, Yang H, Huang JW, Yi S, Zhang M, Cai N, Zhang L, Ding Q, Lai K, Liu C, Zhang L, Liu X, Yao Y, Zhou S, Li X, Shen P, Chang Q, Malwal SR, He Y, Li W, Chen C, Chen CC, Oldfield E, Guo RT, Zhang Y. Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature. 2023 Sep;621(7980):840-848. doi: 10.1038/s41586-023-06525-3. Epub 2023 Sep 6. PMID: 37674084; PMCID: PMC10533412.

November 7, 2023

Wenyi Li (Feske Lab)

Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J Exp Med. 2024 Jan 1;221(1):e20222178. doi: 10.1084/jem.20222178. Epub 2023 Oct 30. PMID: 37902601; PMCID: PMC10615893.

October 31, 2023

Rabi Upadhyay (Littman Lab)

Alanko J, Uçar MC, Canigova N, Stopp J, Schwarz J, Merrin J, Hannezo E, Sixt M. CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration. Sci Immunol. 2023 Sep;8(87):eadc9584. doi: 10.1126/sciimmunol.adc9584. Epub 2023 Sep 1. PMID: 37656776.

Carla Nowosad

Sender R, Weiss Y, Navon Y, Milo I, Azulay N, Keren L, Fuchs S, Ben-Zvi D, Noor E, Milo R. The total mass, number, and distribution of immune cells in the human body. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2308511120. doi: 10.1073/pnas.2308511120. Epub 2023 Oct 23. PMID: 37871201.

October 24, 2023

Lucile Noyer (Feske Lab)

Park E, Barclay WE, Barrera A, Liao TC, Salzler HR, Reddy TE, Shinohara ML, Ciofani M. Integrin α3 promotes TH17 cell polarization and extravasation during autoimmune neuroinflammation. Sci Immunol. 2023 Oct 20;8(88):eadg7597. doi: 10.1126/sciimmunol.adg7597. Epub 2023 Oct 13. PMID: 37831759.

Alan Varghese (Littman and Nudler Labs)

Machado H, Hofer P, Zechner R, Smith TK, Figueiredo LM. Adipocyte lipolysis protects mice against Trypanosoma brucei infection. Nat Microbiol. 2023 Oct 12. doi: 10.1038/s41564-023-01496-7. Epub ahead of print. PMID: 37828246.

Quintana JF, Sinton MC, Chandrasegaran P, Lestari AN, Heslop R, Cheaib B, Ogunsola J, Ngoyi DM, Kuispond Swar NR, Cooper A, Mabbott NA, Coffelt SB, MacLeod A. γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection. Nat Commun. 2023 Aug 29;14(1):5279. doi: 10.1038/s41467-023-40962-y. PMID: 37644007; PMCID: PMC10465518.

Redford SE, Varanasi SK, Sanchez KK, Thorup NR, Ayres JS. CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection. Cell Rep. 2023 Aug 29;42(8):112814. doi: 10.1016/j.celrep.2023.112814. Epub 2023 Jul 24. PMID: 37490905.

October 17, 2023

Anthony Tao (Feske Lab)

Arroyo-Díaz NM, Bachus H, Papillion A, Randall TD, Akther J, Rosenberg AF, León B, Ballesteros-Tato A. Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses. Immunity. 2023 Oct 10;56(10):2358-2372.e5. doi: 10.1016/j.immuni.2023.08.015. Epub 2023 Sep 11. PMID: 37699392.

October 10, 2023

Susan Schwab

Rüterbusch MJ, Hondowicz BD, Takehara KK, Pruner KB, Griffith TS, Pepper M. Allergen exposure functionally alters influenza-specific CD4+ Th1 memory cells in the lung. J Exp Med. 2023 Nov 6;220(11):e20230112. doi: 10.1084/jem.20230112. Epub 2023 Sep 12. PMID: 37698553; PMCID: PMC10497397.

Areli Lopez Bujanda (Littman Lab)

Tremain AC, Wallace RP, Lorentz KM, Thornley TB, Antane JT, Raczy MR, Reda JW, Alpar AT, Slezak AJ, Watkins EA, Maulloo CD, Budina E, Solanki A, Nguyen M, Bischoff DJ, Harrington JL, Mishra R, Conley GP, Marlin R, Dereuddre-Bosquet N, Gallouët AS, LeGrand R, Wilson DS, Kontos S, Hubbell JA. Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses. Nat Biomed Eng. 2023 Sep;7(9):1142-1155. doi: 10.1038/s41551-023-01086-2. Epub 2023 Sep 7. PMID: 37679570.

October 3, 2023

Filio Karakousi (Lund Lab)

Brown H, Komnick MR, Brigleb PH, Dermody TS, Esterházy D. Lymph node sharing between pancreas, gut, and liver leads to immune crosstalk and regulation of pancreatic autoimmunity. Immunity. 2023 Sep 12;56(9):2070-2085.e11. doi: 10.1016/j.immuni.2023.07.008. Epub 2023 Aug 8. PMID: 37557168.

Yuelin Song (Littman Lab)

Frascoli M, Ferraj E, Miu B, Malin J, Spidale NA, Cowan J, Shissler SC, Brink R, Xu Y, Cyster JG, Bhandoola A, Kang J, Reboldi A. Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol. Immunity. 2023 Mar 14;56(3):562-575.e6. doi: 10.1016/j.immuni.2023.01.025. Epub 2023 Feb 25. PMID: 36842431; PMCID: PMC10306310.

September 26, 2023

Pei-Feng Hsu (Reizis Lab)

Vanneste D, Bai Q, Hasan S, Peng W, Pirottin D, Schyns J, Maréchal P, Ruscitti C, Meunier M, Liu Z, Legrand C, Fievez L, Ginhoux F, Radermecker C, Bureau F, Marichal T. MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation. Nat Immunol. 2023 May;24(5):827-840. doi: 10.1038/s41590-023-01468-3. Epub 2023 Mar 16. PMID: 36928411; PMCID: PMC10154211.

Joe Pucella (Reizis Lab)

Siracusa F, Schaltenberg N, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N. Short-term dietary changes can result in mucosal and systemic immune depression. Nat Immunol. 2023 Sep;24(9):1473-1486. doi: 10.1038/s41590-023-01587-x. Epub 2023 Aug 14. PMID: 37580603; PMCID: PMC10457203.

September 19, 2023

Dan Littman

Gu X, Nardone C, Kamitaki N, Mao A, Elledge SJ, Greenberg ME. The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation. Science. 2023 Aug 25;381(6660):eadh5021. doi: 10.1126/science.adh5021. Epub 2023 Aug 25. PMID: 37616343.

Ethan Tardio (Krogsgaard Lab)

Zhang DKY, Adu-Berchie K, Iyer S, Liu Y, Cieri N, Brockman JM, Neuberg D, Wu CJ, Mooney DJ. Enhancing CAR-T cell functionality in a patient-specific manner. Nat Commun. 2023 Jan 31;14(1):506. doi: 10.1038/s41467-023-36126-7. PMID: 36720856; PMCID: PMC9889707.

September 12, 2023

Tariq Najar (Littman Lab)

Nagashima K, Zhao A, Atabakhsh K, Bae M, Blum JE, Weakley A, Jain S, Meng X, Cheng AG, Wang M, Higginbottom S, Dimas A, Murugkar P, Sattely ES, Moon JJ, Balskus EP, Fischbach MA. Mapping the T cell repertoire to a complex gut bacterial community. Nature. 2023 Sep;621(7977):162-170. doi: 10.1038/s41586-023-06431-8. Epub 2023 Aug 16. PMID: 37587342.

September 5, 2023

Tiger Wang (Feske Lab)

Liu B, Carlson RJ, Pires IS, Gentili M, Feng E, Hellier Q, Schwartz MA, Blainey PC, Irvine DJ, Hacohen N. Human STING is a proton channel. Science. 2023 Aug 4;381(6657):508-514. doi: 10.1126/science.adf8974. Epub 2023 Aug 3. PMID: 37535724.

Amanda Lund

Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, Sharma S, Krummel MF, Chi H, Bensinger SJ, Goldrath AW. Metabolic programs of T cell tissue residency empower tumour immunity. Nature. 2023 Aug 30. doi: 10.1038/s41586-023-06483-w. Epub ahead of print. PMID: 37648857.

August 29, 2023

Ipsita Subudhi (Naik Lab)

Sanmarco LM, Rone JM, Polonio CM, Fernandez Lahore G, Giovannoni F, Ferrara K, Gutierrez-Vazquez C, Li N, Sokolovska A, Plasencia A, Faust Akl C, Nanda P, Heck ES, Li Z, Lee HG, Chao CC, Rejano-Gordillo CM, Fonseca-Castro PH, Illouz T, Linnerbauer M, Kenison JE, Barilla RM, Farrenkopf D, Stevens NA, Piester G, Chung EN, Dailey L, Kuchroo VK, Hava D, Wheeler MA, Clish C, Nowarski R, Balsa E, Lora JM, Quintana FJ. Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells. Nature. 2023 Aug 9. doi: 10.1038/s41586-023-06409-6. Epub ahead of print. PMID: 37558878.

Kai Mesa (Littman Lab)

Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA. Platelet factors attenuate inflammation and rescue cognition in ageing. Nature. 2023 Aug 16. doi: 10.1038/s41586-023-06436-3. Epub ahead of print. PMID: 37587343.

August 22, 2023

Juan Lafaille

Florsheim EB, Bachtel ND, Cullen JL, Lima BGC, Godazgar M, Carvalho F, Chatain CP, Zimmer MR, Zhang C, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature. 2023 Jul 12. doi: 10.1038/s41586-023-06362-4. Epub ahead of print. PMID: 37437602.

Plum T, Binzberger R, Thiele R, Shang F, Postrach D, Fung C, Fortea M, Stakenborg N, Wang Z, Tappe-Theodor A, Poth T, MacLaren DAA, Boeckxstaens G, Kuner R, Pitzer C, Monyer H, Xin C, Bonventre JV, Tanaka S, Voehringer D, Vanden Berghe P, Strid J, Feyerabend TB, Rodewald HR. Mast cells link immune sensing to antigen-avoidance behaviour. Nature. 2023 Jul 12. doi: 10.1038/s41586-023-06188-0. Epub ahead of print. PMID: 37438525.

August 15, 2023

Hailin Tu (Littman Lab)

He K, Wan T, Wang D, Hu J, Zhou T, Tao W, Wei Z, Lu Q, Zhou R, Tian Z, Flavell RA, Zhu S. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023 Jul 6;186(14):3033-3048.e20. doi: 10.1016/j.cell.2023.05.027. Epub 2023 Jun 15. PMID: 37327784.

Taejin Yun (Reizis Lab)

Ugur M, Labios RJ, Fenton C, Knöpper K, Jobin K, Imdahl F, Golda G, Hoh K, Grafen A, Kaisho T, Saliba AE, Grün D, Gasteiger G, Bajénoff M, Kastenmüller W. Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks. Immunity. 2023 Aug 8;56(8):1778-1793.e10. doi: 10.1016/j.immuni.2023.06.020. Epub 2023 Jul 17. PMID: 37463581.

August 8, 2023

Liuhui Fu (Littman Lab)

Endo Y, Kanno T, Nakajima T, Ikeda K, Taketomi Y, Yokoyama S, Sasamoto S, Asou HK, Miyako K, Hasegawa Y, Kawashima Y, Ohara O, Murakami M, Nakayama T. 1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in TH17 cells. Sci Immunol. 2023 Aug 4;8(86):eadd4346. doi: 10.1126/sciimmunol.add4346. Epub 2023 Aug 4. PMID: 37540735.

Luan Firmino Cruz (Nowosad Lab)

Sharma R, Smolkin RM, Chowdhury P, Fernandez KC, Kim Y, Cols M, Alread W, Yen WF, Hu W, Wang ZM, Violante S, Chaligné R, Li MO, Cross JR, Chaudhuri J. Distinct metabolic requirements regulate B cell activation and germinal center responses. Nat Immunol. 2023 Aug;24(8):1358-1369. doi: 10.1038/s41590-023-01540-y. Epub 2023 Jun 26. PMID: 37365386.

August 1, 2023

Liwei Wang (Feske Lab)

Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H.SLC38A2 and glutamine signaling in cDC1s dictate anti-tumour immunity. Nature. 2023 Jul 5. doi: 10.1038/s41586-023-06299-8. Epub ahead of print. PMID: 37407815.

July 25, 2023

Nick Adams (Reizis Lab)

Silva-Sanchez A, Meza-Perez S, Liu M, Stone SL, Flores-Romo L, Ubil E, Lund FE, Rosenberg AF, Randall TD. Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. Sci Immunol. 2023 Jun 23;8(84):eadc9081. doi: 10.1126/sciimmunol.adc9081. Epub 2023 Jun 16. PMID: 37327322; PMCID: PMC10351240.

July 11, 2023

Boris Reizis

Bosteels V, Maréchal S, De Nolf C, Rennen S, Maelfait J, Tavernier SJ, Vetters J, Van De Velde E, Fayazpour F, Deswarte K, Lamoot A, Van Duyse J, Martens L, Bosteels C, Roelandt R, Emmaneel A, Van Gassen S, Boon L, Van Isterdael G, Guillas I, Vandamme N, Höglinger D, De Geest BG, Le Goff W, Saeys Y, Ravichandran KS, Lambrecht BN, Janssens S. LXR signaling controls homeostatic dendritic cell maturation. Sci Immunol. 2023 May 12;8(83):eadd3955. doi: 10.1126/sciimmunol.add3955. Epub 2023 May 12. PMID: 37172103.

Li Zhong (Feske Lab)

Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617(7960):386-394. doi: 10.1038/s41586-023-06017-4. Epub 2023 Apr 26. PMID: 37100912; PMCID: PMC10131557.

June 27, 2023

Tenny Mudianto (Lund Lab)

Lütge M, De Martin A, Gil-Cruz C, Perez-Shibayama C, Stanossek Y, Onder L, Cheng HW, Kurz L, Cadosch N, Soneson C, Robinson MD, Stoeckli SJ, Ludewig B, Pikor NB. Conserved stromal-immune cell circuits secure B cell homeostasis and function. Nat Immunol. 2023 May 18. doi: 10.1038/s41590-023-01503-3. Epub ahead of print. PMID: 37202489.

Laetitia Weinhard (Littman Lab)

Schonhoff AM, Figge DA, Williams GP, Jurkuvenaite A, Gallups NJ, Childers GM, Webster JM, Standaert DG, Goldman JE, Harms AS. 2023. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease. Nature Communications 14: 3754

June 13, 2023

Taylor Heim (Lund Lab)

Giles JR, Ngiow SF, Manne S, Baxter AE, Khan O, Wang P, Staupe R, Abdel-Hakeem MS, Huang H, Mathew D, Painter MM, Wu JE, Huang YJ, Goel RR, Yan PK, Karakousis GC, Xu X, Mitchell TC, Huang AC, Wherry EJ. Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics. Nat Immunol. 2022 Nov;23(11):1600-1613. doi: 10.1038/s41590-022-01338-4. Epub 2022 Oct 21. PMID: 36271148.

Annesa Das (Reizis Lab)

Laurent P, Yang C, Rendeiro AF, Nilsson-Payant BE, Carrau L, Chandar V, Bram Y, tenOever BR, Elemento O, Ivashkiv LB, Schwartz RE, Barrat FJ. Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19. Sci Immunol. 2022 Sep 9;7(75):eadd4906. doi: 10.1126/sciimmunol.add4906. Epub 2022 Sep 9. PMID: 36083891; PMCID: PMC9853436.

June 6, 2023

Katie Ventre (Lund Lab)

Prokhnevska N, Cardenas MA, Valanparambil RM, Sobierajska E, Barwick BG, Jansen C, Reyes Moon A, Gregorova P, delBalzo L, Greenwald R, Bilen MA, Alemozaffar M, Joshi S, Cimmino C, Larsen C, Master V, Sanda M, Kissick H. CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor. Immunity. 2023 Jan 10;56(1):107-124.e5. doi: 10.1016/j.immuni.2022.12.002. Epub 2022 Dec 28. PMID: 36580918.

Payal Damani-Yokota (Khanna Lab)

Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. The enteric nervous system relays psychological stress to intestinal inflammation. Cell. 2023 May 22:S0092-8674(23)00475-0. doi: 10.1016/j.cell.2023.05.001. Epub ahead of print. PMID: 37236193.

May 30, 2023

Francis Chen (Littman Lab)

Silva-Cayetano A, Fra-Bido S, Robert PA, Innocentin S, Burton AR, Watson EM, Lee JL, Webb LMC, Foster WS, McKenzie RCJ, Bignon A, Vanderleyden I, Alterauge D, Lemos JP, Carr EJ, Hill DL, Cinti I, Balabanian K, Baumjohann D, Espeli M, Meyer-Hermann M, Denton AE, Linterman MA. Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging. Nat Immunol. 2023 May 22. doi: 10.1038/s41590-023-01519-9. Epub ahead of print. PMID: 37217705.

Jasper Du (Wang Lab)

Suzuki K, Tajima M, Tokumaru Y, Oshiro Y, Nagata S, Kamada H, Kihara M, Nakano K, Honjo T, Ohta A. Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases. Sci Immunol. 2023 Jan 13;8(79):eadd4947. doi: 10.1126/sciimmunol.add4947. Epub 2023 Jan 13. PMID: 36638191.

May 16, 2023

Rabi Upadhyay (Littman Lab)

Park JS, Gazzaniga FS, Wu M, Luthens AK, Gillis J, Zheng W, LaFleur MW, Johnson SB, Morad G, Park EM, Zhou Y, Watowich SS, Wargo JA, Freeman GJ, Kasper DL, Sharpe AH. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May;617(7960):377-385. doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3. PMID: 37138075.

Velmurugu Yogambigai (Krogsgaard Lab)

Keppler-Hafkemeyer A, Greil C, Wratil PR, Shoumariyeh K, Stern M, Hafkemeyer A, Ashok D, Hollaus A, Lupoli G, Priller A, Bischof ML, Ihorst G, Engelhardt M, Marks R, Finke J, Bertrand H, Dächert C, Muenchhoff M, Badell I, Emmerich F, Halder H, Spaeth PM, Knolle PA, Protzer U, von Bergwelt-Baildon M, Duyster J, Hartmann TN, Moosmann A, Keppler OT. Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma. Nat Cancer. 2023 Jan;4(1):81-95. doi: 10.1038/s43018-022-00502-x. Epub 2022 Dec 21. PMID: 36543907; PMCID: PMC9886553.

May 9, 2023

Alan Varghese (Littman and Nudler Labs)

Torow N, Li R, Hitch TCA, Mingels C, Al Bounny S, van Best N, Stange EL, Simons B, Maié T, Rüttger L, Gubbi NMKP, Abbott DA, Benabid A, Gadermayr M, Runge S, Treichel N, Merhof D, Rosshart SP, Jehmlich N, Hand TW, von Bergen M, Heymann F, Pabst O, Clavel T, Tacke F, Lelouard H, Costa IG, Hornef MW. M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch. Immunity. 2023 Apr 21:S1074-7613(23)00170-X. doi: 10.1016/j.immuni.2023.04.002. Epub ahead of print. PMID: 37130522.

Wenyi Li (Feske Lab)

Gocher-Demske AM, Cui J, Szymczak-Workman AL, Vignali KM, Latini JN, Pieklo GP, Kimball JC, Avery L, Cipolla EM, Huckestein BR, Hedden L, Meisel M, Alcorn JF, Kane LP, Workman CJ, Vignali DAA. IFNγ-induction of TH1-like regulatory T cells controls antiviral responses. Nat Immunol. 2023 May;24(5):841-854. doi: 10.1038/s41590-023-01453-w. Epub 2023 Mar 16. PMID: 36928412.

May 2, 2023

Joseph Saglimbeni (Reizis Lab)

Marx AF, Kallert SM, Brunner TM, Villegas JA, Geier F, Fixemer J, Abreu-Mota T, Reuther P, Bonilla WV, Fadejeva J, Kreutzfeldt M, Wagner I, Aparicio-Domingo P, Scarpellino L, Charmoy M, Utzschneider DT, Hagedorn C, Lu M, Cornille K, Stauffer K, Kreppel F, Merkler D, Zehn D, Held W, Luther SA, Löhning M, Pinschewer DD. The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection. Immunity. 2023 Apr 11;56(4):813-828.e10. doi: 10.1016/j.immuni.2023.01.029. Epub 2023 Feb 20. PMID: 36809763.

Anthony Tao (Feske Lab)

Chen ST, Oliveira TY, Gazumyan A, Cipolla M, Nussenzweig MC. B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection. Immunity. 2023 Mar 14;56(3):547-561.e7. doi: 10.1016/j.immuni.2023.02.003. Epub 2023 Mar 6. PMID: 36882061.

April 25, 2023

Lucile Noyer (Feske Lab)

Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M. TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer. Nat Immunol. 2023 Apr 20. doi: 10.1038/s41590-023-01475-4. Epub ahead of print. PMID: 37081148.

April 18, 2023

Susan Schwab

Chen YE, Bousbaine D, Veinbachs A, Atabakhsh K, Dimas A, Yu VK, Zhao A, Enright NJ, Nagashima K, Belkaid Y, Fischbach MA. Engineered skin bacteria induce antitumor T cell responses against melanoma. Science. 2023 Apr 14;380(6641):203-210. doi: 10.1126/science.abp9563. Epub 2023 Apr 13. PMID: 37053311.

Ryan Curtin (Krogsgaard Lab)

Gao F, Mallajoysula V, Arunachalam PS, van der Ploeg K, Manohar M, Röltgen K, Yang F, Wirz O, Hoh R, Haraguchi E, Lee JY, Willis R, Ramachandiran V, Li J, Kathuria KR, Li C, Lee AS, Shah MM, Sindher SB, Gonzalez J, Altman JD, Wang TT, Boyd SD, Pulendran B, Jagannathan P, Nadeau KC, Davis MM. Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection. Immunity. 2023 Apr 11;56(4):864-878.e4. doi: 10.1016/j.immuni.2023.03.005. Epub 2023 Mar 16. PMID: 36996809; PMCID: PMC10017386.

April 11, 2023

Ying-Han Chen (Cadwell Lab)

Gurtner A, Borrelli C, Gonzalez-Perez I, Bach K, Acar IE, Núñez NG, Crepaz D, Handler K, Vu VP, Lafzi A, Stirm K, Raju D, Gschwend J, Basler K, Schneider C, Slack E, Valenta T, Becher B, Krebs P, Moor AE, Arnold IC. Active eosinophils regulate host defence and immune responses in colitis. Nature. 2023 Mar;615(7950):151-157. doi: 10.1038/s41586-022-05628-7. Epub 2022 Dec 12. PMID: 36509106; PMCID: PMC9977678.

April 4, 2023

Lucie Bernard (Cadwell Lab)

Hanna BS, Wang G, Galván-Peña S, Mann AO, Ramirez RN, Muñoz-Rojas AR, Smith K, Wan M, Benoist C, Mathis D. The gut microbiota promotes distal tissue regeneration via RORγ+regulatory T cell emissaries. Immunity. 2023 Feb 14:S1074-7613(23)00045-6. doi: 10.1016/j.immuni.2023.01.033. Epub ahead of print. PMID: 36822206.

Yuelin Song (Littman Lab)

Sikder, M. A. A., R. B. Rashid, T. Ahmed, I. Sebina, D. Howard, M. A. Ullah, M. M. Rahman, J. P. Lynch, B. Curren, R. B. Werder, J. Simpson, A. Bissell, M. Morrison, C. Walpole, K. J. Radford, V. Kumar, T. M. Woodruff, T. HuiYing, A. Ali, G. E. Kaiko, J. W. Upham, R. D. Hoelzle, P. Ó. Cuív, P. G. Holt, P. G. Dennis and S. Phipps (2023). The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis. bioRxiv: 2023.2001.2005.522516.

March 28, 2023

Zoe Ciantra (Jun Wang Lab)

Linde MH, Fan AC, Kohnke T, Trotman-Grant AC, Gurev SF, Phan P, Zhao F, Haddock NL, Nuno KA, Gars EJ, Stafford M, Marshall PL, Dove CG, Linde IL, Landberg N, Miller LP, Majzner RG, Zhang TY, Majeti R. Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy. Cancer Discov. 2023 Mar 1:CD-21-0502. doi: 10.1158/2159-8290.CD-21-0502. Epub ahead of print. PMID: 36856575.

Taylor Heim (Lund Lab)

Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D. Functional T cells are capable of supernumerary cell division and longevity. Nature. 2023 Feb;614(7949):762-766. doi: 10.1038/s41586-022-05626-9. Epub 2023 Jan 18. PMID: 36653453.

March 21, 2023

Serap Erdogmus (Feske Lab)

Côrte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M. Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. Cell Metab. 2023 Feb 7;35(2):299-315.e8. doi: 10.1016/j.cmet.2023.01.009. PMID: 36754020.

Elaine Camacho-Hernández (Davoli Lab)

Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, Grootjans J, Pyzik M, Sommer F, Kaiser S, Falk-Paulsen M, Grasberger H, Kao JY, Fuhrer T, Li H, Paik D, Lee Y, Refetoff S, Glickman JN, Paton AW, Bry L, Paton JC, Sauer U, Macpherson AJ, Rosenstiel P, Kuchroo VK, Waldor MK, Huh JR, Kaser A, Blumberg RS. Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut. Immunity. 2023 Mar 7:S1074-7613(23)00092-4. doi: 10.1016/j.immuni.2023.02.018. Epub ahead of print. PMID: 36917985.

March 14, 2023

Alice Kwon (Littman and Liddelow Labs)

Bin NR, Prescott SL, Horio N, Wang Y, Chiu IM, Liberles SD. An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature. 2023 Mar 8. doi: 10.1038/s41586-023-05796-0. Epub ahead of print. PMID: 36890237.

March 7, 2023

Kyung Ku Jang (Cadwell Lab)

Funsten MC, Yurkovetskiy LA, Kuznetsov A, Reiman D, Hansen CHF, Senter KI, Lee J, Ratiu J, Dahal-Koirala S, Antonopoulos DA, Dunny GM, Sollid LM, Serreze D, Khan AA, Chervonsky AV. Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes. Cell Host Microbe. 2023 Feb 8;31(2):213-227.e9. doi: 10.1016/j.chom.2022.12.009. Epub 2023 Jan 4. PMID: 36603588; PMCID: PMC9911364.

Pei-Feng Hsu (Reizis Lab)

Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK. Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Immunity. 2023 Feb 14:S1074-7613(23)00036-5. doi: 10.1016/j.immuni.2023.01.024. Epub ahead of print. PMID: 36827982.

February 28, 2023

Tariq Najar (Littman Lab)

Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT, Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX, Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT, Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM, Samsom JN, Goettel JA. Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell Rep. 2023 Feb 17;42(2):112128. doi: 10.1016/j.celrep.2023.112128. Epub ahead of print. PMID: 36807140.

February 28, 2023

Dan Littman

Katzmarski N, Domínguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, Lepikhov K, Kattler K, Gasparoni G, Händler K, Theis H, Beyer M, van der Meer JWM, Joosten LAB, Walter J, Schultze JL, Roger T, Giamarellos-Bourboulis EJ, Schlitzer A, Netea MG. Transmission of trained immunity and heterologous resistance to infections across generations. Nat Immunol. 2021 Nov;22(11):1382-1390. doi: 10.1038/s41590-021-01052-7. Epub 2021 Oct 18. Erratum in: Nat Immunol. 2023 Feb;24(2):371-372. PMID: 34663978.

Takahashi Y, Morales Valencia M, Yu Y, Ouchi Y, Takahashi K, Shokhirev MN, Lande K, Williams AE, Fresia C, Kurita M, Hishida T, Shojima K, Hatanaka F, Nuñez-Delicado E, Esteban CR, Izpisua Belmonte JC. Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice. Cell. 2023 Feb 16;186(4):715-731.e19. doi: 10.1016/j.cell.2022.12.047. Epub 2023 Feb 7. PMID: 36754048.

Eugene Rudensky (Cadwell Lab)

Pallett LJ, Swadling L, Diniz M, Maini AA, Schwabenland M, Gasull AD, Davies J, Kucykowicz S, Skelton JK, Thomas N, Schmidt NM, Amin OE, Gill US, Stegmann KA, Burton AR, Stephenson E, Reynolds G, Whelan M, Sanchez J, de Maeyer R, Thakker C, Suveizdyte K, Uddin I, Ortega-Prieto AM, Grant C, Froghi F, Fusai G, Lens S, Pérez-Del-Pulgar S, Al-Akkad W, Mazza G, Noursadeghi M, Akbar A, Kennedy PTF, Davidson BR, Prinz M, Chain BM, Haniffa M, Gilroy DW, Dorner M, Bengsch B, Schurich A, Maini MK. Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS.Nature. 2023 Feb;614(7947):334-342. doi: 10.1038/s41586-022-05645-6. Epub 2023 Jan 25. PMID: 36697826.

February 7, 2023

Filio Karakousi (Lund Lab)

Kemna J, Gout E, Daniau L, Lao J, Weißert K, Ammann S, Kühn R, Richter M, Molenda C, Sporbert A, Zocholl D, Klopfleisch R, Lortat-Jacob H, Aichele P, Kammertoens T, Blankenstein T. IFNγ binding to extracellular matrix prevents fatal systemic toxicity. Nat Immunol. 2023 Feb 2. doi: 10.1038/s41590-023-01420-5. Epub ahead of print. PMID: 36732425.

Tiger Wang (Feske Lab)

Enamorado M, Kulalert W, Han SJ, Rao I, Delaleu J, Link VM, Yong D, Smelkinson M, Gil L, Nakajima S, Linehan JL, Bouladoux N, Wlaschin J, Kabat J, Kamenyeva O, Deng L, Gribonika I, Chesler AT, Chiu IM, Le Pichon CE, Belkaid Y. Immunity to the microbiota promotes sensory neuron regeneration. Cell. 2023 Feb 2;186(3):607-620.e17. doi: 10.1016/j.cell.2022.12.037. Epub 2023 Jan 13. PMID: 36640762.

January 31, 2023

Kai Mesa (Littman Lab)

Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Aznar-Benitah S, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature. 2023 Jan;613(7942):169-178. doi: 10.1038/s41586-022-05535-x. Epub 2022 Dec 21. PMID: 36544018; PMCID: PMC9812788.

January 24, 2023

Krystal Ching (Cadwell Lab)

Ceglia S, Berthelette A, Howley K, Li Y, Mortzfeld B, Bhattarai SK, Yiew NKH, Xu Y, Brink R, Cyster JG, Hooper LV, Randolph GJ, Bucci V, Reboldi A. An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells. Nat Immunol. 2023 Jan 19. doi: 10.1038/s41590-022-01413-w. Epub ahead of print. PMID: 36658240.

Ipsita Subudhi (Naik Lab)

Earley ZM, Lisicka W, Sifakis JJ, Aguirre-Gamboa R, Kowalczyk A, Barlow JT, Shaw DG, Discepolo V, Tan IL, Gona S, Ernest JD, Matzinger P, Barreiro LB, Morgun A, Bendelac A, Ismagilov RF, Shulzhenko N, Riesenfeld SJ, Jabri B. GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 Jan 10;56(1):43-57.e10. doi: 10.1016/j.immuni.2022.12.009. PMID: 36630917.

January 17, 2023

Juan Lafaille

So L, Obata-Ninomiya K, Hu A, Muir VS, Takamori A, Song J, Buckner JH, Savan R, Ziegler SF. Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis. J Exp Med. 2023 Mar 6;220(3):e20221676. doi: 10.1084/jem.20221676. Epub 2023 Jan 4. PMID: 36598533; PMCID: PMC9827529.

January 10, 2023

Areli Lopez Bujanda (Littman Lab)

Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024. Epub 2022 Oct 14. PMID: 36243004; PMCID: PMC9617795.

December 20, 2022

Nick Adams (Reizis Lab)

Odell ID, Steach H, Gauld SB, Reinke-Breen L, Karman J, Carr TL, Wetter JB, Phillips L, Hinchcliff M, Flavell RA. Epiregulin is a dendritic cell-derived EGFR ligand that maintains skin and lung fibrosis. Sci Immunol. 2022 Dec 16;7(78):eabq6691. doi: 10.1126/sciimmunol.abq6691. Epub 2022 Dec 9. PMID: 36490328.

Christin Herrmann (Cadwell Lab)

Zou J, Ngo VL, Wang Y, Wang Y, Gewirtz AT. Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity. Cell Host Microbe. 2022 Nov 11:S1931-3128(22)00527-3. doi: 10.1016/j.chom.2022.10.014. Epub ahead of print. PMID: 36493784.

December 13, 2022

Boris Reizis

Kotov, Dmitri I., Ophelia V. Lee, Charlotte Langner, Jaresley V. Guillen, Joshua M. Peters, Andres Moon, Eileen M. Burd, Kristen C. Witt, Daniel B. Stetson, David L. Jaye, Bryan D. Bryson, and Russell E. Vance. 2022. Cellular sources and targets of type I interferons that drive susceptibility to tuberculosis, bioRxiv: 2022.10.06.511233

Laetitia Weinhard (Littman Lab)

Haimon Z, Frumer GR, Kim JS, Trzebanski S, Haffner-Krausz R, Ben-Dor S, Porat Z, Muschaweckh A, Chappell-Maor L, Boura-Halfon S, Korn T, Jung S. Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology. Nat Immunol. 2022 Dec 1. doi: 10.1038/s41590-022-01360-6. Epub ahead of print. PMID: 36456736.

December 6, 2022

Payal Damani-Yokota (Khanna Lab)

Block KE, Iijima K, Pierson MJ, Walsh DA, Tei R, Kucaba TA, Xu J, Khan MH, Staley C, Griffith TS, McSorley HJ, Kita H, Jameson SC. Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens. Nat Immunol. 2022 Nov 21. doi: 10.1038/s41590-022-01350-8. Epub ahead of print. PMID: 36411381.

Xiaomin Yao (Cadwell Lab)

Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity. 2022 Nov 9:S1074-7613(22)00562-3. doi: 10.1016/j.immuni.2022.10.021. Epub ahead of print. PMID: 36384135.

November 29, 2022

Tenny Mudianto (Lund Lab)

Denton AE, Dooley J, Cinti I, Silva-Cayetano A, Fra-Bido S, Innocentin S, Hill DL, Carr EJ, McKenzie ANJ, Liston A, Linterman MA. Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response. Sci Immunol. 2022 May 6;7(71):eabk0018. doi: 10.1126/sciimmunol.abk0018. Epub 2022 May 6. PMID: 35522725; PMCID: PMC7612953.

Mariya London (Cadwell Lab)

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022 Nov 8;55(11):2059-2073.e8. doi: 10.1016/j.immuni.2022.09.014. Epub 2022 Oct 19. PMID: 36351375.

November 22, 2022

Amanda Lund

Niño JLG, Wu H, LaCourse KD, Kempchinsky AG, Baryiames A, Barber B, Futran N, Houlton J, Sather C, Sicinska E, Taylor A, Minot SS, Johnston CD, Bullman S. Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer. Nature. 2022 Nov 16. doi: 10.1038/s41586-022-05435-0. Epub ahead of print. PMID: 36385528.

Ethan Tardio (Krogsgaard Lab)

Purcarea A, Jarosch S, Barton J, Grassmann S, Pachmayr L, D'Ippolito E, Hammel M, Hochholzer A, Wagner KI, van den Berg JH, Buchholz VR, Haanen JBAG, Busch DH, Schober K. Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity. Sci Immunol. 2022 Aug 12;7(74):eabm2077. doi: 10.1126/sciimmunol.abm2077. Epub 2022 Aug 12. PMID: 35960818.

November 15, 2022

Joe Pucella (Reizis Lab)

McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ, Wong LP, Yates AG, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge MP, Swirski FK. Sleep exerts lasting effects on hematopoietic stem cell function and diversity. J Exp Med. 2022 Nov 7;219(11):e20220081. doi: 10.1084/jem.20220081. Epub 2022 Sep 21. PMID: 36129517; PMCID: PMC9499822.

Jasper Du (Wang Lab)

Li B, Lu Y, Zhong MC, Qian J, Li R, Davidson D, Tang Z, Zhu K, Argenty J, de Peredo AG, Malissen B, Roncagalli R, Veillette A. Cis interactions between CD2 and its ligands on T cells are required for T cell activation. Sci Immunol. 2022 Aug 5;7(74):eabn6373. doi: 10.1126/sciimmunol.abn6373. Epub 2022 Aug 5. PMID: 35930657.

November 8, 2022

Katie Ventre (Lund Lab)

Cui G, Shimba A, Jin J, Ogawa T, Muramoto Y, Miyachi H, Abe S, Asahi T, Tani-Ichi S, Dijkstra JM, Iwamoto Y, Kryukov K, Zhu Y, Takami D, Hara T, Kitano S, Xu Y, Morita H, Zhang M, Zreka L, Miyata K, Kanaya T, Okumura S, Ito T, Hatano E, Takahashi Y, Watarai H, Oike Y, Imanishi T, Ohno H, Ohteki T, Minato N, Kubo M, Holländer GA, Ueno H, Noda T, Shiroguchi K, Ikuta K. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022 Oct 28;7(76):eabj8760. doi: 10.1126/sciimmunol.abj8760. Epub 2022 Oct 21. PMID: 36269840.

Li Zhong (Feske Lab)

Fang D, Cui K, Cao Y, Zheng M, Kawabe T, Hu G, Khillan JS, Li D, Zhong C, Jankovic D, Sher A, Zhao K, Zhu J. Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation. Immunity. 2022 Apr 12;55(4):639-655.e7. doi: 10.1016/j.immuni.2022.03.005. Epub 2022 Apr 4. PMID: 35381213; PMCID: PMC9059963.

November 1, 2022

Francis Chen (Littman Lab)

Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA. An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice. Science. 2022 Oct 21;378(6617):290-295. doi: 10.1126/science.abn9886. Epub 2022 Oct 20. PMID: 36264814.

Velmurugu Yogambigai (Krogsgaard Lab)

Voisinne G, Locard-Paulet M, Froment C, Maturin E, Menoita MG, Girard L, Mellado V, Burlet-Schiltz O, Malissen B, Gonzalez de Peredo A, Roncagalli R. Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discrimination. Nat Immunol. 2022 Sep;23(9):1355-1364. doi: 10.1038/s41590-022-01288-x. Epub 2022 Aug 31. PMID: 36045187; PMCID: PMC9477740.

October 25, 2022

Nikhita Kirthivasan (Littman Lab)

Kabat AM, Hackl A, Sanin DE, Zeis P, Grzes KM, Baixauli F, Kyle R, Caputa G, Edwards-Hicks J, Villa M, Rana N, Curtis JD, Castoldi A, Cupovic J, Dreesen L, Sibilia M, Pospisilik JA, Urban JF Jr, Grün D, Pearce EL, Pearce EJ. Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection. Sci Immunol. 2022 Oct 21;7(76):eadd3263. doi: 10.1126/sciimmunol.add3263. Epub 2022 Oct 14. PMID: 36240286.

October 18, 2022

Rabi Upadhyay (Littman Lab)

Liu Y, Zhou J, Li X, Zhang X, Shi J, Wang X, Li H, Miao S, Chen H, He X, Dong L, Lee GR, Zheng J, Liu RJ, Su B, Ye Y, Flavell RA, Yi C, Wu Y, Li HB. tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis. Nat Immunol. 2022 Oct;23(10):1433-1444. doi: 10.1038/s41590-022-01301-3. Epub 2022 Sep 22. PMID: 36138184.

October 11, 2022

Alan Varghese (Littman and Nudler Labs)

Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC. Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 Sep 30;377(6614):1519-1529. doi: 10.1126/science.abj5104. Epub 2022 Sep 29. PMID: 36173860.

Anthony Tao (Feske Lab)

Li S, Mirlekar B, Johnson BM, Brickey WJ, Wrobel JA, Yang N, Song D, Entwistle S, Tan X, Deng M, Cui Y, Li W, Vincent BG, Gale M Jr, Pylayeva-Gupta Y, Ting JP. STING-induced regulatory B cells compromise NK function in cancer immunity. Nature. 2022 Oct 5. doi: 10.1038/s41586-022-05254-3. Epub ahead of print. PMID: 36198789.

October 4, 2022

Lucile Noyer (Feske Lab)

Baixauli F, Piletic K, Puleston DJ, Villa M, Field CS, Flachsmann LJ, Quintana A, Rana N, Edwards-Hicks J, Matsushita M, Stanczak MA, Grzes KM, Kabat AM, Fabri M, Caputa G, Kelly B, Corrado M, Musa Y, Duda KJ, Mittler G, O'Sullivan D, Sesaki H, Jenuwein T, Buescher JM, Pearce EJ, Sanin DE, Pearce EL. An LKB1-mitochondria axis controls TH17 effector function. Nature. 2022 Sep 28. doi: 10.1038/s41586-022-05264-1. Epub ahead of print. PMID: 36171294.

Joseph Saglimbeni (Reizis Lab)

Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity. 2022 Sep 13;55(9):1609-1626.e7. doi: 10.1016/j.immuni.2022.07.007. Epub 2022 Aug 12. PMID: 35963236; PMCID: PMC9474643.

September 27, 2022

Ryan Curtin (Krogsgaard Lab)

Diniz MO, Mitsi E, Swadling L, Rylance J, Johnson M, Goldblatt D, Ferreira D, Maini MK. Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2. Nat Immunol. 2022 Sep;23(9):1324-1329. doi: 10.1038/s41590-022-01292-1. Epub 2022 Aug 29. PMID: 36038709; PMCID: PMC9477726.

Amicha Robertson (Cadwell Lab)

Erttmann SF, Swacha P, Aung KM, Brindefalk B, Jiang H, Härtlova A, Uhlin BE, Wai SN, Gekara NO. The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis. Immunity. 2022 May 10;55(5):847-861.e10. doi: 10.1016/j.immuni.2022.04.006. PMID: 35545033.

September 20, 2022

Ken Cadwell

Ariën Schiepers, Marije F. L. van ’t Wout, Allison J. Greaney, Trinity Zang, HiromiMuramatsu, Paulo J. C. Lin, Ying K. Tam, Luka Mesin, Tyler N. Starr, Paul D. Bieniasz, Norbert Pardi, Jesse D. Bloom, Gabriel D. Victora. Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization. bioRxiv 2022.08.29.505743

Annesa Das (Reizis Lab)

Lança T, Ungerbäck J, Da Silva C, Joeris T, Ahmadi F, Vandamme J, Svensson-Frej M, Mowat AM, Kotarsky K, Sigvardsson M, Agace WW. IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage. Immunity. 2022 Aug 9;55(8):1431-1447.e11. doi: 10.1016/j.immuni.2022.06.006. Epub 2022 Jul 12. PMID: 35830859.

September 13, 2022

Ying-Han Chen (Cadwell Lab)

Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Nature. 2022 Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6. Epub 2022 Jun 29. PMID: 35768505.

Yuelin Song (Littman Lab)

Kawano Y, Edwards M, Huang Y, Bilate AM, Araujo LP, Tanoue T, Atarashi K, Ladinsky MS, Reiner SL, Wang HH, Mucida D, Honda K, Ivanov II. Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. Cell. 2022 Aug 24:S0092-8674(22)00992-8. doi: 10.1016/j.cell.2022.08.005. Epub ahead of print. PMID: 36041436.

September 6, 2022

Taylor Heim (Lund Lab)

Fonseca R, Burn TN, Gandolfo LC, Devi S, Park SL, Obers A, Evrard M, Christo SN, Buquicchio FA, Lareau CA, McDonald KM, Sandford SK, Zamudio NM, Zanluqui NG, Zaid A, Speed TP, Satpathy AT, Mueller SN, Carbone FR, Mackay LK. Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells. Nat Immunol. 2022 Aug;23(8):1236-1245. doi: 10.1038/s41590-022-01273-4. Epub 2022 Jul 26. PMID: 35882933.

Lucie Bernard (Cadwell Lab)

Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, Di Santo JP, Serafini N. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat Immunol. 2022 Aug 23. doi: 10.1038/s41590-022-01284-1. Epub ahead of print. PMID: 35999393.

August 30, 2022

Jun Wang

Sugiura D, Okazaki IM, Maeda TK, Maruhashi T, Shimizu K, Arakaki R, Takemoto T, Ishimaru N, Okazaki T. PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nat Immunol. 2022 Mar;23(3):399-410. doi: 10.1038/s41590-021-01125-7. Epub 2022 Feb 10. PMID: 35145298.

Serap Erdogmus (Feske Lab)

Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. PMID: 35835107; PMCID: PMC9378606.

August 23, 2022

Alice Kwon (Littman and Liddelow Labs)

Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, McAlpine CS, Xu C, Kahles F, He S, Janssen H, Mindur JE, Singh S, Kiss MG, Alonso-Herranz L, Iwamoto Y, Kohler RH, Wong LP, Chetal K, Russo SJ, Sadreyev RI, Weissleder R, Nahrendorf M, Frenette PS, Divangahi M, Swirski FK. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022 Jul;607(7919):578-584. doi: 10.1038/s41586-022-04890-z. Epub 2022 May 30. PMID: 35636458.

Anna Halling Andersen (Krogsgaard Lab)

Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, Kuo F, Zhang J, Zhang X, Capistrano K, Blum KA, Weiss K, Kedl RM, Cui G, Ikuta K, Chan TA, Leslie CS, Hakimi AA, Li MO. Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 2022 Jun;23(6):904-915. doi: 10.1038/s41590-022-01213-2. Epub 2022 May 26. Erratum in: Nat Immunol. 2022 Jun 15;: PMID: 35618834; PMCID: PMC9202504.

August 16, 2022

Susan Schwab

Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK. Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction. Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6. PMID: 35794484.

August 9, 2022

Amanda Lund

Dähling S, Mansilla AM, Knöpper K, Grafen A, Utzschneider DT, Ugur M, Whitney PG, Bachem A, Arampatzi P, Imdahl F, Kaisho T, Zehn D, Klauschen F, Garbi N, Kallies A, Saliba AE, Gasteiger G, Bedoui S, Kastenmüller W. Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches. Immunity. 2022 Apr 12;55(4):656-670.e8. doi: 10.1016/j.immuni.2022.03.006. Epub 2022 Apr 1. PMID: 35366396.

Tong Deng (Littman Lab)

Choi J, Chen W, Minkina A, Chardon FM, Suiter CC, Regalado SG, Domcke S, Hamazaki N, Lee C, Martin B, Daza RM, Shendure J. A time-resolved, multi-symbol molecular recorder via sequential genome editing. Nature. 2022 Aug;608(7921):98-107. doi: 10.1038/s41586-022-04922-8. Epub 2022 Jul 6. PMID: 35794474.

August 2, 2022

Alannah Lejeune (Cadwell Lab)

Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD. Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 Jul 27. doi: 10.1038/s41586-022-05005-4. Epub ahead of print. PMID: 35896747.

Pei-Feng Hsu (Reizis Lab)

Li F, Piattini F, Pohlmeier L, Feng Q, Rehrauer H, Kopf M. Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Sci Immunol. 2022 Jul;7(73):eabj5761. doi: 10.1126/sciimmunol.abj5761. Epub 2022 Jul 1. PMID: 35776802.

July 26, 2022

Kai Mesa (Littman Lab)

Zhou L, Kong G, Palmisano I, Cencioni MT, Danzi M, De Virgiliis F, Chadwick JS, Crawford G, Yu Z, De Winter F, Lemmon V, Bixby J, Puttagunta R, Verhaagen J, Pospori C, Lo Celso C, Strid J, Botto M, Di Giovanni S. Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline. Science. 2022 May 13;376(6594):eabd5926. doi: 10.1126/science.abd5926. Epub 2022 May 13. PMID: 35549409.

Yu Matsuzawa (Cadwell Lab)

Ghosh S, Kumar M, Santiana M, Mishra A, Zhang M, Labayo H, Chibly AM, Nakamura H, Tanaka T, Henderson W, Lewis E, Voss O, Su Y, Belkaid Y, Chiorini JA, Hoffman MP, Altan-Bonnet N. Enteric viruses replicate in salivary glands and infect through saliva. Nature. 2022 Jul;607(7918):345-350. doi: 10.1038/s41586-022-04895-8. Epub 2022 Jun 29. PMID: 35768512; PMCID: PMC9243862.

July 19, 2022

Dan Littman

Campisi L, Chizari S, Ho JSY, Gromova A, Arnold F, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 Jun;606(7916):945-952. doi: 10.1038/s41586-022-04844-5. Epub 2022 Jun 22. PMID: 35732742.

Stela Sota (Cadwell Lab)

Serger E, Luengo-Gutierrez L, Chadwick JS, Kong G, Zhou L, Crawford G, Danzi MC, Myridakis A, Brandis A, Bello AT, Müller F, Sanchez-Vassopoulos A, De Virgiliis F, Liddell P, Dumas ME, Strid J, Mani S, Dodd D, Di Giovanni S. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature. 2022 Jun 22. doi: 10.1038/s41586-022-04884-x. Epub ahead of print. PMID: 35732737.

July 12, 2022

Filio Karakousi (Lund Lab)

Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. Circadian clocks guide dendritic cells into skin lymphatics. Nat Immunol. 2021 Nov;22(11):1375-1381. doi: 10.1038/s41590-021-01040-x. Epub 2021 Oct 18. PMID: 34663979; PMCID: PMC8553624.

Eugene Rudensky (Cadwell Lab)

Zhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness. Cell. 2022 Jun 28:S0092-8674(22)00641-9. doi: 10.1016/j.cell.2022.05.016. Epub ahead of print. PMID: 35777355.

July 5, 2022

Tiger Wang (Feske Lab)

Liu Z, Hu X, Liang Y, Yu J, Li H, Shokhirev MN, Zheng Y. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. Nat Immunol. 2022 Jun 23. doi: 10.1038/s41590-022-01244-9. Epub ahead of print. PMID: 35739197.

Elaine Camacho-Hernández (Davoli Lab)

Jou E, Rodriguez-Rodriguez N, Ferreira AF, Jolin HE, Clark PA, Sawmynaden K, Ko M, Murphy JE, Mannion J, Ward C, Matthews DJ, Buczacki SJA, McKenzie ANJ. An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc mutation-driven intestinal tumorigenesis. Sci Immunol. 2022 Jun 3;7(72):eabn0175. doi: 10.1126/sciimmunol.abn0175. Epub 2022 Jun 3. PMID: 35658010; PMCID: PMC7612821.

June 28, 2022

Juan Lafaille

Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 Apr;604(7905):337-342. doi: 10.1038/s41586-022-04536-0. Epub 2022 Mar 30. PMID: 35355021; PMCID: PMC9165753.

Ipsita Subudhi (Naik Lab)

Shi K, Li H, Chang T, He W, Kong Y, Qi C, Li R, Huang H, Zhu Z, Zheng P, Ruan Z, Zhou J, Shi FD, Liu Q. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. 2022 Jun 23;185(13):2234-2247.e17. doi: 10.1016/j.cell.2022.05.020. Epub 2022 Jun 15. PMID: 35709748.

June 21, 2022

Krystal Ching (Cadwell Lab)

Ignacio A, Shah K, Bernier-Latmani J, Köller Y, Coakley G, Moyat M, Hamelin R, Armand F, Wong NC, Ramay H, Thomson CA, Burkhard R, Wang H, Dufour A, Geuking MB, McDonald B, Petrova TV, Harris NL, McCoy KD. Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization. Immunity. 2022 Jun 7:S1074-7613(22)00234-5. doi: 10.1016/j.immuni.2022.05.014. Epub ahead of print. PMID: 35709757.

Tariq Najar (Littman Lab)

Michelson DA, Hase K, Kaisho T, Benoist C, Mathis D. Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells. Cell. 2022 Jun 12:S0092-8674(22)00649-3. doi: 10.1016/j.cell.2022.05.018. Epub ahead of print. PMID: 35714609.

June 14, 2022

Liwei Wang (Feske Lab)

Badrinath S, Dellacherie MO, Li A, Zheng S, Zhang X, Sobral M, Pyrdol JW, Smith KL, Lu Y, Haag S, Ijaz H, Connor-Stroud F, Kaisho T, Dranoff G, Yuan GC, Mooney DJ, Wucherpfennig KW. A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature. 2022 May 25. doi: 10.1038/s41586-022-04772-4. Epub ahead of print. PMID: 35614223.

Ranit Kedmi (Littman Lab)

Shinzawa M, Moseman EA, Gossa S, Mano Y, Bhattacharya A, Guinter T, Alag A, Chen X, Cam M, McGavern DB, Erman B, Singer A. Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nat Immunol. 2022 May;23(5):731-742. doi: 10.1038/s41590-022-01187-1. Epub 2022 Apr 29. PMID: 35523960; PMCID: PMC9098387.

May 24, 2022

Tenny Mudianto (Lund)

Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell. 2021 Dec 9;184(25):6101-6118.e13. doi: 10.1016/j.cell.2021.11.007. Epub 2021 Nov 30. PMID: 34852236; PMCID: PMC8671355.

Areli Lopez Bujanda (Littman)

Viola M.F., Chavero-Pieres M., Modave E., Stakenborg N., Delfini M., Fabre N., Iris Appeltans1, Martens T., Vandereyken K., Van Herck J., Petry P., Verheijden S., De Schepper S., Sifrim A., Kierdorf K., Prinz M., Vanden Berghe P., Voet T., and Boeckxstaens G. Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood 

https://www.biorxiv.org/content/10.1101/2022.05.12.491517v1

May 17, 2022

Nikhita Kirthivasan (Littman)

Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022 May 1:S0092-8674(22)00466-4. doi: 10.1016/j.cell.2022.04.019. Epub ahead of print. PMID: 35525247.

Velmurugu Yogambigai (Krogsgaard)

Guy C, Mitrea DM, Chou PC, Temirov J, Vignali KM, Liu X, Zhang H, Kriwacki R, Bruchez MP, Watkins SC, Workman CJ, Vignali DAA. LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation. Nat Immunol. 2022 Apr 18. doi: 10.1038/s41590-022-01176-4. Epub ahead of print. PMID: 35437325.

May 10, 2022

Rabi Upadhyay (Littman)

Larson RC, Kann MC, Bailey SR, Haradhvala NJ, Llopis PM, Bouffard AA, Scarfó I, Leick MB, Grauwet K, Berger TR, Stewart K, Anekal PV, Jan M, Joung J, Schmidts A, Ouspenskaia T, Law T, Regev A, Getz G, Maus MV. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature. 2022 Apr;604(7906):563-570. doi: 10.1038/s41586-022-04585-5. Epub 2022 Apr 13. PMID: 35418687.

Alan Varghese (Littman/Nudler)

Yang H, Wu J, Huang X, Zhou Y, Zhang Y, Liu M, Liu Q, Ke S, He M, Fu H, Fang S, Xiong X, Jiang H, Chen Z, Wu Z, Gong H, Tong X, Huang Y, Ma J, Gao J, Charlier C, Coppieters W, Shagam L, Zhang Z, Ai H, Yang B, Georges M, Chen C, Huang L. ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs. Nature. 2022 Apr 27. doi: 10.1038/s41586-022-04769-z. Epub ahead of print. PMID: 35477154.

SPRINGER GF, HORTON RE, FORBES M. [Origin of anti-human blood group B agglutinins in white Leghorn chicks]. J Exp Med. 1959 Aug 1;110(2):221-44. doi: 10.1084/jem.110.2.221. PMID: 13673136; PMCID: PMC2136992.

May 3, 2022

Ryan Curtin (Krogsgaard)

Sabatino JJ Jr, Mittl K, Rowles WM, McPolin K, Rajan JV, Laurie MT, Zamecnik CR, Dandekar R, Alvarenga BD, Loudermilk RP, Gerungan C, Spencer CM, Sagan SA, Augusto DG, Alexander JR, DeRisi JL, Hollenbach JA, Wilson MR, Zamvil SS, Bove R. Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine-induced antibody and T cell immunity and function. JCI Insight. 2022 Feb 22;7(4):e156978. doi: 10.1172/jci.insight.156978. PMID: 35030101; PMCID: PMC8876469.

Alice Kwon (Littman/Liddelow)

Gabanyi I, Lepousez G, Wheeler R, Vieites-Prado A, Nissant A, Wagner S, Moigneu C, Dulauroy S, Hicham S, Polomack B, Verny F, Rosenstiel P, Renier N, Boneca IG, Eberl G, Lledo PM. Bacterial sensing via neuronal Nod2 regulates appetite and body temperature. Science. 2022 Apr 15;376(6590):eabj3986. doi: 10.1126/science.abj3986. Epub 2022 Apr 15. PMID: 35420957.

April 26, 2022

Mariya London (Cadwell)

Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. Programme of self-reactive innate-like T cell-mediated cancer immunity. Nature. 2022 Apr 20. doi: 10.1038/s41586-022-04632-1. Epub ahead of print. PMID: 35444279.

Taylor Heim (Lund)

Snell LM, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod BL, Elsaesser HJ, Hezaveh K, Alsahafi N, Lukhele S, Nejat S, Prabhakaran R, Epelman S, McGaha TL, Brooks DG. Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection. Nat Immunol. 2021 Dec;22(12):1524-1537. doi: 10.1038/s41590-021-01060-7. Epub 2021 Nov 18. PMID: 34795443.

April 19, 2022

Yuelin Song (Littman)

Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A. Establishment of fetomaternal tolerance through glycan-mediated B cell suppression. Nature. 2022 Mar;603(7901):497-502. doi: 10.1038/s41586-022-04471-0. Epub 2022 Mar 2. PMID: 35236989.

April 12, 2022

Lucie Bernard (Cadwell)

Teh CE, Preston SP, Robbins AK, Stutz MD, Cooney J, Clark MP, Policheni AN, Allison CC, Mackiewicz L, Arandjelovic P, Ebert G, Doerflinger M, Tan T, Rankin LC, Teh PP, Belz GT, Kallies A, Strasser A, Pellegrini M, Gray DHD. Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage. Sci Immunol. 2022 Mar 25;7(69):eabn8041. doi: 10.1126/sciimmunol.abn8041. Epub 2022 Mar 25. PMID: 35333545.

Axel Concepcion (Feske)

Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman JA, Xue X, Lu C, Lu L, Mimitou EP, Hao S, Davoli T, Diefenbach C, Smibert P, Sanjana NE. A genome-scale screen for synthetic drivers of T cell proliferation. Nature. 2022 Mar;603(7902):728-735. doi: 10.1038/s41586-022-04494-7. Epub 2022 Mar 16. PMID: 35296855.

April 5, 2022

Anthony Tao (Feske)

Long Z, Phillips B, Radtke D, Meyer-Hermann M, Bannard O. Competition for refueling rather than cyclic reentry initiation evident in germinal centers. Sci Immunol. 2022 Mar 11;7(69):eabm0775. doi: 10.1126/sciimmunol.abm0775. Epub 2022 Mar 11. PMID: 35275753.

Kai Mesa (Littman)

Paterson N, Lämmermann T. Macrophage network dynamics depend on haptokinesis for optimal local surveillance. Elife. 2022 Mar 28;11:e75354. doi: 10.7554/eLife.75354. PMID: 35343899; PMCID: PMC8963880.

March 29, 2022

Nick Adams (Reizis)

Heinlein M, Gandolfo LC, Zhao K, Teh CE, Nguyen N, Baell JB, Goldfarb Y, Abramson J, Wichmann J, Voss AK, Strasser A, Smyth GK, Thomas T, Gray DHD. The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance. Sci. Immunol. 2022 Jan 21;7(67):eabb6032. doi: 10.1126./sciimmunol.abb6032.

Alara Tuncer (Littman)

Cosway, E.J., White, A.J., Parnell, S.M., Schweighoffer, E., Jolin, H.E., Bacon, A., Rodewald, H.R., Tybulewicz, V., McKenzie, A.N., Jenkinson, W.E. and Anderson, G., 2022. Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration. Science Immunology, 7(69), p.eabn3286.

March 22, 2022

Ali Rashidfarrokhi (Papagiannakopoulos)

Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Röger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Heneghan HM, Hogan AE, O'Shea D, Fallon PG. Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity. Sci Transl Med. 2022 Mar 9;14(635):eabj6879. doi: 10.1126/scitranslmed.abj6879. Epub 2022 Mar 9. PMID: 35263149.

Eugene Rudensky (Cadwell)

Zhang J, Yu Q, Jiang D, Yu K, Yu W, Chi Z, Chen S, Li M, Yang D, Wang Z, Xu T, Guo X, Zhang K, Fang H, Ye Q, He Y, Zhang X, Wang D. Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. Sci Immunol. 2022 Feb 4;7(68):eabk2092. doi: 10.1126/sciimmunol.abk2092. Epub 2022 Feb 4. PMID: 35119941.

March 15, 2022

Yue Xing (Naik)

Raymond MH, Davidson AJ, Shen Y, Tudor DR, Lucas CD, Morioka S, Perry JSA, Krapivkina J, Perrais D, Schumacher LJ, Campbell RE, Wood W, Ravichandran KS. Live cell tracking of macrophage efferocytosis during Drosophilaembryo development in vivo. Science. 2022 Mar 11;375(6585):1182-1187. doi: 10.1126/science.abl4430. Epub 2022 Mar 10. PMID: 35271315.

Tiger Wang (Feske)

Fueyo-González, F., McGinty, M., Ningoo, M., Anderson, L., Cantarelli, C., Andrea Angeletti, Demir, M., Llaudó, I., Purroy, C., Marjanovic, N., Heja, D., Sealfon, S. C., Heeger, P. S., Cravedi, P., & Fribourg, M. (2022). Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation. Immunity, 55(3), 459-474.e7.

March 8, 2022

Joe Pucella (Reizis)

Schriek P, Ching AC, Moily NS, Moffat J, Beattie L, Steiner TM, Hosking LM, Thurman JM, Holers VM, Ishido S, Lahoud MH, Caminschi I, Heath WR, Mintern JD, Villadangos JA. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science. 2022 Feb 11;375(6581):eabf7470. doi: 10.1126/science.abf7470. Epub 2022 Feb 11. PMID: 35143312.

Ipsita Subudhi (Naik)

McKenzie DR, Hart R, Bah N, Ushakov DS, Muñoz-Ruiz M, Feederle R, Hayday AC. Normality sensing licenses local T cells for innate-like tissue surveillance. Nat Immunol. 2022 Feb 14. doi: 10.1038/s41590-021-01124-8. Epub ahead of print. PMID: 35165446.

March 1, 2022

Oriana Perez (Reizis)

Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 Feb 11;375(6581):eabi5965. doi: 10.1126/science.abi5965. Epub 2022 Feb 11. PMID: 35143305.

Tariq Najar (Littman)

Serafini N, Jarade A, Surace L, Goncalves P, Sismeiro O, Varet H, Legendre R, Coppee JY, Disson O, Durum SK, Frankel G, Di Santo JP. Trained ILC3 responses promote intestinal defense. Science. 2022 Feb 25;375(6583):859-863. doi: 10.1126/science.aaz8777. Epub 2022 Feb 24. PMID: 35201883.

February 22, 2022

Xiaomin Yao (Cadwell)

De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell. 2022 Feb 3:S0092-8674(22)00068-X. doi: 10.1016/j.cell.2022.01.010. Epub ahead of print. PMID: 35148838.

February 15, 2022

Christin Herrmann (Cadwell)

Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio A. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science. 2022 Jan 21;375(6578):296-301. doi: 10.1126/science.abj8222. Epub 2022 Jan 13. PMID: 35025605.

Lanz TV, Brewer RC, Ho PP, Moon J , Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj G, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, Cotham VC, Ueberheide BM, Aftab BT, Anderson MS, DeRisi JL, Wilson MR, Bashford-Rogers RJM, Platten M, Garcia KC, Steinman L, Robinson WH. Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM. Nature. 2022 Jan 24. doi: 10.1038/s41586-022-04432-7. Online ahead of print. PMID: 35073561.

Varsha Raghavan (Littman)

Moustaki A, Crawford JC, Alli S, Fan Y, Boi S, Zamora AE, McDonald NMN, Wu G, Nakitandwe J, Newman S, Foy S, Silkov A, Thomas PG, Pappo A, Dyer MA, Stewart E, Federico S, Youngblood B. Antigen cross-presentation in young tumor-bearing hosts promotes CD8+ T cell terminal differentiation. Sci Immunol. 2022 Feb 4;7(68):eabf6136. doi: 10.1126/sciimmunol.abf6136. Epub 2022 Feb 4. PMID: 35119937.

February 8, 2022

Doua Azzouz (Silverman)

Song W, Antao OQ, Condiff E, Sanchez GM, Chernova I, Zembrzuski K, Steach H, Rubtsova K, Angeletti D, Lemenze A, Laidlaw BJ, Craft J, Weinstein JS. Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers. Immunity. 2022 Jan 21:S1074-7613(22)00031-0. doi: 10.1016/j.immuni.2022.01.002. Epub ahead of print. PMID: 35090581.

Payal Damani-Yokota (Khanna)

Amorim A, De Feo D, Friebel E, Ingelfinger F, Anderfuhren CD, Krishnarajah S, Andreadou M, Welsh CA, Liu Z, Ginhoux F, Greter M, Becher B. IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation. Nat Immunol. 2022 Feb;23(2):217-228. doi: 10.1038/s41590-021-01117-7. Epub 2022 Jan 31. PMID: 35102344.

February 1, 2022

Areli Lopez Bujanda (Littman)

Tamar Koren, Re’ee Yifa, Mariam Amer, Maria Krot, Nadia Boshnak, Tamar L. Ben-Shaanan, Hilla Azulay-Debby, Itay Zalayat, Eden Avishai, Haitham Hajjo, Maya Schiller, Hedva Haykin, Ben Korin, Dorit Farfara, Fahed Hakim, Oren Kobiler, Kobi Rosenblum, Asya Rolls. Insular cortex neurons encode and retrieve specific immune responses. Cell, 2021 Nov 24;184(24):5902-5915.e17. doi: 10.1016/j.cell.2021.10.013. Epub 2021 Nov 8.

Liwei Wang (Feske)

Lötscher J, Martí I Líndez AA, Kirchhammer N, Cribioli E, Giordano G, Trefny MP, Lenz M, Rothschild SI, Strati P, Künzli M, Lotter C, Schenk SH, Dehio P, Löliger J, Litzler L, Schreiner D, Koch V, Page N, Lee D, Grählert J, Kuzmin D, Burgener AV, Merkler D, Pless M, Balmer ML, Reith W, Huwyler J, Irving M, King CG, Zippelius A, Hess C. Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell. 2022 Jan 13:S0092-8674(21)01561-0. doi: 10.1016/j.cell.2021.12.039. Epub ahead of print. PMID: 35051368.

January 25, 2022

Ying-Han Chen (Cadwell)

Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier. Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450. Epub 2021 Dec 24. PMID: 34941394.

Tenny Mudianto (Lund)

Wu D, Poholek CH, Majumder S, Liu Q, Revu SK, Mohib K, Rothstein DM, McGeachy MJ. IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells. Sci Immunol. 2021 Dec 17;6(66):eaao3669. doi: 10.1126/sciimmunol.aao3669. Epub 2021 Dec 17. PMID: 34919443.

January 18, 2022

Ian Harvey (Littman)

Sugiura, A., Andrejeva, G., Voss, K., Heintzman, D. R., Xu, X., Madden, M. Z., Ye, X., Beier, K. L., Chowdhury, N. U., Wolf, M. M., Young, A. C., Greenwood, D. L., Sewell, A. E., Shahi, S. K., Freedman, S. N., Cameron, A. M., Foerch, P., Bourne, T., Garcia-Canaveras, J. C., . . . Rathmell, J. C. (2022). MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity, 55(1), 65-81.e69.

Ryan Curtin (Krogsgaard)

Kundu R, Narean JS, Wang L, Fenn J, Pillay T, Fernandez ND, Conibear E, Koycheva A, Davies M, Tolosa-Wright M, Hakki S, Varro R, McDermott E, Hammett S, Cutajar J, Thwaites RS, Parker E, Rosadas C, McClure M, Tedder R, Taylor GP, Dunning J, Lalvani A. Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts. Nat Commun. 2022 Jan 10;13(1):80. doi: 10.1038/s41467-021-27674-x. PMID: 35013199.

January 11, 2022

Lucile Noyer (Feske)

Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell. 2021 Nov 18:S1535-6108(21)00602-4. doi: 10.1016/j.ccell.2021.11.002. Epub ahead of print. PMID: 34822775.

Rabi Upadhyay (Littman)

Rurik JG, Tombácz I, Yadegari A, Méndez Fernández PO, Shewale SV, Li L, Kimura T, Soliman OY, Papp TE, Tam YK, Mui BL, Albelda SM, Puré E, June CH, Aghajanian H, Weissman D, Parhiz H, Epstein JA. CAR T cells produced in vivo to treat cardiac injury. Science. 2022 Jan 7;375(6576):91-96. doi: 10.1126/science.abm0594. Epub 2022 Jan 6. PMID: 34990237.

January 4, 2022

Taylor Heim (Lund)

Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC. Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells. Immunity. 2021 Dec 14:S1074-7613(21)00509-4. doi: 10.1016/j.immuni.2021.11.017. Epub ahead of print. PMID: 34932944.

Velmurugu Yogambigai (Krogsgaard)

Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O; UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ. mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021 Dec 3;374(6572):abm0829. doi: 10.1126/science.abm0829. Epub 2021 Dec 3. PMID: 34648302.

December 21, 2021

Yuelin Song (Littman)

Kim E, Paik D, Ramirez RN, Biggs DG, Park Y, Kwon HK, Choi GB, Huh JR. Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+T cells. Immunity. 2021 Nov 30:S1074-7613(21)00496-9. doi: 10.1016/j.immuni.2021.11.005. Epub ahead of print. PMID: 34879222.

Mariya London (Cadwell)

Thapa P, Guyer RS, Yang AY, Parks CA, Brusko TM, Brusko M, Connors TJ, Farber DL. Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling. Sci Immunol. 2021 Dec 10;6(66):eabj0789. doi: 10.1126/sciimmunol.abj0789. Epub 2021 Dec 10. PMID: 34890254.

December 14, 2021

Axel Concepcion (Feske)

Schnell A, Huang L, Singer M, Singaraju A, Barilla RM, Regan BML, Bollhagen A, Thakore PI, Dionne D, Delorey TM, Pawlak M, Meyer Zu Horste G, Rozenblatt-Rosen O, Irizarry RA, Regev A, Kuchroo VK. Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021 Nov 30:S0092-8674(21)01333-7. doi: 10.1016/j.cell.2021.11.018. Epub ahead of print. PMID: 34875227.

Boris Reizis

Caielli S, Cardenas J, de Jesus AA, Baisch J, Walters L, Blanck JP, Balasubramanian P, Stagnar C, Ohouo M, Hong S, Nassi L, Stewart K, Fuller J, Gu J, Banchereau JF, Wright T, Goldbach-Mansky R, Pascual V. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell. 2021 Aug 19;184(17):4464-4479.e19. doi: 10.1016/j.cell.2021.07.021. Epub 2021 Aug 11. PMID: 34384544; PMCID: PMC8380737.

December 7, 2021

Hao Xu (Littman)

Liu S, Wang Z, Su Y, Qi L, Yang W, Fu M, Jing X, Wang Y, Ma Q. A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis. Nature. 2021 Oct;598(7882):641-645. doi: 10.1038/s41586-021-04001-4. Epub 2021 Oct 13. PMID: 34646018.

Lucie Bernard (Cadwell)

Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells. Sci Immunol. 2021 Nov 5;6(65):eabf7235. doi: 10.1126/sciimmunol.abf7235. Epub 2021 Nov 5. PMID: 34739338.

November 30, 2021

Tony Tao (Feske)

Trindade, B. C., S. Ceglia, A. Berthelette, F. Raso, K. Howley, J. R. Muppidi, and A. Reboldi. 2021. The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation. Immunity 54: 2273-2287.e6.

Kai Mesa (Littman)

Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. 2021. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. Oct 29;374(6567):eabb3420.

November 23, 2021

Nick Adams (Reizis)

Wang J, Lareau CA, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, Gardner JM. Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium. Sci Immunol. 2021 Nov 12;6(65):eabl5053. doi: 10.1126/sciimmunol.abl5053. Epub 2021 Nov 12. PMID: 34767455.

Alara Tuncer (Littman)

Stehle C, Rückert T, Fiancette R, Gajdasik DW, Willis C, Ulbricht C, Durek P, Mashreghi MF, Finke D, Hauser AE, Withers DR, Chang HD, Zimmermann J, Romagnani C. T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation. Nat Immunol. 2021 Oct;22(10):1231-1244. doi: 10.1038/s41590-021-01029-6. Epub 2021 Sep 23. PMID: 34556887.

November 16, 2021

Ali Rashidfarrokhi (Papagiannakopoulos)

Faas M, Ipseiz N, Ackermann J, Culemann S, Grüneboom A, Schröder F, Rothe T, Scholtysek C, Eberhardt M, Böttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, Wirtz S, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Krönke G. IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5. doi: 10.1016/j.immuni.2021.09.010. Epub 2021 Oct 12. PMID: 34644537.

Eugene Rudensky (Cadwell)

Gaidt MM, Morrow A, Fairgrieve MR, Karr JP, Yosef N, Vance RE. Self-guarding of MORC3 enables virulence factor-triggered immunity. Nature. 2021 Nov 10. doi: 10.1038/s41586-021-04054-5. Epub ahead of print. PMID: 34759314.

November 9, 2021

Yue Xing (Naik)

Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 Oct 27. doi: 10.1038/s41586-021-04044-7. Epub ahead of print. PMID: 34707292.

Tiger Wang (Feske)

Zhang B, Vogelzang A, Miyajima M, Sugiura Y, Wu Y, Chamoto K, Nakano R, Hatae R, Menzies RJ, Sonomura K, Hojo N, Ogawa T, Kobayashi W, Tsutsui Y, Yamamoto S, Maruya M, Narushima S, Suzuki K, Sugiya H, Murakami K, Hashimoto M, Ueno H, Kobayashi T, Ito K, Hirano T, Shiroguchi K, Matsuda F, Suematsu M, Honjo T, Fagarasan S. B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity. Nature. 2021 Nov 3. doi: 10.1038/s41586-021-04082-1. Epub ahead of print. PMID: 34732892.

November 2, 2021

Joe Pucella (Reizis)

Lam LKM, Murphy S, Kokkinaki D, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan AE, Hahn BH, Odom John AR, Meyer NJ, Hunter CA, Worthen GS, Mangalmurti NS. DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia. Sci Transl Med. 2021 Oct 20;13(616):eabj1008. doi: 10.1126/scitranslmed.abj1008. Epub 2021 Oct 20. PMID: 34669439.

Tariq Najar (Littman)

Canale FP, Basso C, Antonini G, Perotti M, Li N, Sokolovska A, Neumann J, James MJ, Geiger S, Jin W, Theurillat JP, West KA, Leventhal DS, Lora JM, Sallusto F, Geiger R. Metabolic modulation of tumours with engineered bacteria for immunotherapy. Nature. 2021 Oct;598(7882):662-666. doi: 10.1038/s41586-021-04003-2. Epub 2021 Oct 6. PMID: 34616044.

October 26, 2021

Oriana Perez (Reizis)

Schenkel JM, Herbst RH, Canner D, Li A, Hillman M, Shanahan SL, Gibbons G, Smith OC, Kim JY, Westcott P, Hwang WL, Freed-Pastor WA, Eng G, Cuoco MS, Rogers P, Park JK, Burger ML, Rozenblatt-Rosen O, Cong L, Pauken KE, Regev A, Jacks T. Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+CD8+ T cells in tumor-draining lymph nodes. Immunity. 2021 Oct 12;54(10):2338-2353.e6. doi: 10.1016/j.immuni.2021.08.026. Epub 2021 Sep 16. PMID: 34534439.

Ranit Kedmi (Littman)

Rollenske T, Burkhalter S, Muerner L, von Gunten S, Lukasiewicz J, Wardemann H, Macpherson AJ. Parallelism of intestinal secretory IgA shapes functional microbial fitness. Nature. 2021 Oct 13. doi: 10.1038/s41586-021-03973-7. Epub ahead of print. PMID: 34646015.

October 19, 2021

Xiaomin Yao (Cadwell)

Wickenhagen A, et al. A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021 Sep 28:eabj3624. doi: 10.1126/science.abj3624. Epub ahead of print. PMID: 34581622.

Varsha Raghavan (Littman)

Lam KC, Araya RE, Huang A, Chen Q, Di Modica M, Rodrigues RR, Lopès A, Johnson SB, Schwarz B, Bohrnsen E, Cogdill AP, Bosio CM, Wargo JA, Lee MP, Goldszmid RS. Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment. Cell. 2021 Oct 14;184(21):5338-5356.e21. doi: 10.1016/j.cell.2021.09.019. Epub 2021 Oct 7. PMID: 34624222.

October 12, 2021

Payal Damani-Yokota (Khanna)

Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ. Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma. Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. PMID: 34525340.

October 5, 2021

Liwei Wang (Feske)

McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14. PMID: 34262178.

Doua Azzouz (Silverman)

Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 Sep 16;184(19):4969-4980.e15. doi: 10.1016/j.cell.2021.07.025. Epub 2021 Jul 23. PMID: 34332650; PMCID: PMC8299219.

September 28, 2021

Dhaval Dixit (Schwab)

Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann T. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021 Jun 18;372(6548):eabe7729. doi: 10.1126/science.abe7729. PMID: 34140358.

Ying-Han Chen (Cadwell)

Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N. Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C. Nature. 2021 Aug;596(7873):570-575. doi: 10.1038/s41586-021-03762-2. Epub 2021 Jul 21. PMID: 34290407.

September 21, 2021

Ryan Curtin (Krogsgaard)

Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021 Sep 14. doi: 10.1038/s41591-021-01507-2. Epub ahead of print. PMID: 34522051.

Ian Harvey (Littman)

Ye-Ji Bang, Zehan Hu, Yun Li, Sureka Gattu, Kelly A. Ruhn, Prithvi Raj, Joachim Herz, Lora V. Hooper. Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity. Science. 2021 Sep 17. doi: 10.1126/science.abf9232

September 14, 2021

Lucile Noyer (Feske)

Sun L, Kees T, Almeida AS, Liu B, He XY, Ng D, Han X, Spector DL, McNeish IA, Gimotty P, Adams S, Egeblad M. Activating a collaborative innate-adaptive immune response to control metastasis. Cancer Cell. 2021 Sep 1:S1535-6108(21)00445-1. doi: 10.1016/j.ccell.2021.08.005. Epub ahead of print. PMID: 34478639.

Rabi Upadhyay (Littman)

Griffin ME, Espinosa J, Becker JL, Luo JD, Carroll TS, Jha JK, Fanger GR, Hang HC. Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy. Science. 2021 Aug 27;373(6558):1040-1046. doi: 10.1126/science.abc9113. PMID: 34446607.

September 7, 2021

Hernandez Moura Silva (Lafaille)

Cardoso F, Klein Wolterink RGJ, Godinho-Silva C, Domingues RG, Ribeiro H, da Silva JA, Mahú I, Domingos AI, Veiga-Fernandes H. Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit. Nature. 2021 Aug 18. doi: 10.1038/s41586-021-03830-7. Epub ahead of print. PMID: 34408322.

Taylor Heim (Lund)

Christo SN, Evrard M, Park SL, Gandolfo LC, Burn TN, Fonseca R, Newman DM, Alexandre YO, Collins N, Zamudio NM, Souza-Fonseca-Guimaraes F, Pellicci DG, Chisanga D, Shi W, Bartholin L, Belz GT, Huntington ND, Lucas A, Lucas M, Mueller SN, Heath WR, Ginhoux F, Speed TP, Carbone FR, Kallies A, Mackay LK. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nat Immunol. 2021 Sep;22(9):1140-1151. doi: 10.1038/s41590-021-01004-1. Epub 2021 Aug 23. PMID: 34426691.

August 31, 2021

Axel Concepcion (Feske)

Christopher B Medina, Yu-Hsin Chiu, Marta E Stremska, Christopher D Lucas, Ivan Poon, Kenneth S Tung, Michael R Elliott, Bimal Desai, Ulrike M Lorenz, Douglas A Bayliss, Kodi S Ravichandran. Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation. Immunity. 2021 Aug 10;54(8):1715-1727.e7. doi: 10.1016/j.immuni.2021.06.014. Epub 2021 Jul 21.

August 24, 2021

Yuelin Song (Littman)

Lima-Junior DS, Krishnamurthy SR, Bouladoux N, Collins N, Han SJ, Chen EY, Constantinides MG, Link VM, Lim AI, Enamorado M, Cataisson C, Gil L, Rao I, Farley TK, Koroleva G, Attig J, Yuspa SH, Fischbach MA, Kassiotis G, Belkaid Y. Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. Cell. 2021 Jul 8;184(14):3794-3811.e19. doi: 10.1016/j.cell.2021.05.020. Epub 2021 Jun 23. PMID: 34166614.

August 17, 2021

Tiger Wang (Feske)

Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kamiński MM, Stanckzak M, Weiss HJ, Grzes KM, Piletic K, Field CS, Corrado M, Haessler F, Wang C, Musa Y, Schimmelpfennig L, Flachsmann L, Mittler G, Yosef N, Kuchroo VK, Buescher JM, Balabanov S, Pearce EJ, Green DR, Pearce EL. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021 Aug 5;184(16):4186-4202.e20. doi: 10.1016/j.cell.2021.06.007. Epub 2021 Jul 2. PMID: 34216540; PMCID: PMC8358979.

August 10, 2021

Anthony Tao (Feske)

Sundling, C., A. W. Y. Lau, K. Bourne, C. Young, C. Laurianto, J. R. Hermes, R. J. Menzies, D. Butt, N. J. Kräutler, D. Zahra, D. Suan, and R. Brink. 2021. Positive selection of IgG+ over IgM+ B cells in the germinal center reaction. Immunity 54: 988-1001.e5.

Kai Mesa (Littman)

Camell CD, Yousefzadeh MJ, Zhu Y, Langhi Prata LGP, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Machado Espindola-Netto J, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Senolytics reduce coronavirus-related mortality in old mice. Science. 2021 Jun 8:eabe4832. doi: 10.1126/science.abe4832. Epub ahead of print. PMID: 34103349. 

Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, Permyakova A, Hinden L, Azar S, Friedmann Y, Kupetz P, Tzuberi R, Anisimov A, Alitalo K, Horwitz M, Leebhoff S, Khoma OZ, Hlushchuk R, Djonov V, Abramovitch R, Tam J, Keshet E. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science. 2021 Jul 30;373(6554):eabc8479. doi: 10.1126/science.abc8479. PMID: 34326210.

August 3, 2021

Nick Adams (Reizis)

Giampazolias E, Schulz O, Lim KHJ, Rogers NC, Chakravarty P, Srinivasan N, Gordon O, Cardoso A, Buck MD, Poirier EZ, Canton J, Zelenay S, Sammicheli S, Moncaut N, Varsani-Brown S, Rosewell I, Reis E Sousa C. Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity. Cell. 2021 Jul 22;184(15):4016-4031.e22. doi: 10.1016/j.cell.2021.05.021. Epub 2021 Jun 2. PMID: 34081922.

Audrey Baeyens (Schwab)

Han, Y.-H., E.J. Onufer, L.-H. Huang, R.W. Sprung, W.S. Davidson, R.S. Czepielewski, M. Wohltmann, M.G. Sorci-Thomas, B.W. Warner, and G.J. Randolph, Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science, 2021. 373(6553): p. eabe6729.

July 27, 2021

Eugene Rudensky (Cadwell)

Poirier EZ, Buck MD, Chakravarty P, Carvalho J, Frederico B, Cardoso A, Healy L, Ulferts R, Beale R, Reis E Sousa C. An isoform of Dicer protects mammalian stem cells against multiple RNA viruses. Science. 2021 Jul 9;373(6551):231-236. doi: 10.1126/science.abg2264. PMID: 34244417.

July 20, 2021

Lin Wu (Littman)

Cox N, Crozet L, Holtman IR, Loyher PL, Lazarov T, White JB, Mass E, Stanley ER, Elemento O, Glass CK, Geissmann F. Diet-regulated production of PDGFcc by macrophages controls energy storage. Science. 2021 Jul 2;373(6550):eabe9383. doi: 10.1126/science.abe9383. PMID: 34210853.

Ali Rashidfarrokhi (Papagiannakopoulos)

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ. Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021 Jul 2;6(61):eabi7083. doi: 10.1126/sciimmunol.abi7083. PMID: 34215680.

July 13, 2021

Yue Xing (Naik)

Hoeffel G, Debroas G, Roger A, Rossignol R, Gouilly J, Laprie C, Chasson L, Barbon PV, Balsamo A, Reynders A, Moqrich A, Ugolini S. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature. 2021 Jun;594(7861):94-99. doi: 10.1038/s41586-021-03563-7. Epub 2021 May 19. PMID: 34012116.

Tariq Najar (Littman)

Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv. 2021 Jul 7;7(28):eabg5859. doi: 10.1126/sciadv.abg5859. PMID: 34233878.

July 6, 2021

Joe Pucella (Reizis)

Tian L, Tomei S, Schreuder J, Weber TS, Amann-Zalcenstein D, Lin DS, Tran J, Audiger C, Chu M, Jarratt A, Willson T, Hilton A, Pang ES, Patton T, Kelly M, Su S, Gouil Q, Diakumis P, Bahlo M, Sargeant T, Kats LM, Hodgkin PD, O'Keeffe M, Ng AP, Ritchie ME, Naik SH. Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development. Immunity. 2021 Jun 8;54(6):1338-1351.e9. doi: 10.1016/j.immuni.2021.03.012. Epub 2021 Apr 15. PMID: 33862015.

Ranit Kedmi (Littman)

Wu J, Wu C, Xing F, Cao L, Zeng W, Guo L, Li P, Zhong Y, Jiang H, Luo M, Shi G, Bu L, Ji Y, Hou P, Peng H, Huang J, Li C, Guo D. Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells. Cell Res. 2021 Jun 22:1–13. doi: 10.1038/s41422-021-00524-7. Epub ahead of print. PMID: 34158624; PMCID: PMC8217788.

June 22, 2021

Christin Herrmann (Cadwell)

Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B, Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Kopf M, Ruzsics Z, Henneke P. Cytomegalovirus subverts macrophage identity. Cell. 2021 Jun 5;S0092-8674(21)00626-7. doi: 10.1016/j.cell.2021.05.009.

Alice Kwon (Littman, Liddelow)

Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, Bando JK, Jaeger N, Czepielewski RS, Swain A, Mogilenko DA, Beatty WL, Bayguinov P, Fitzpatrick JAJ, Schuettpelz LG, Fronick CC, Smirnov I, Kipnis J, Shapiro VS, Wu GF, Gilfillan S, Cella M, Artyomov MN, Kleinstein SH, Colonna M. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021 Jun 3:eabf9277. doi: 10.1126/science.abf9277. Epub ahead of print. PMID: 34083450.

June 15, 2021

Xiaomin Yao (Cadwell)

Gensollen T, Lin X, Zhang T, Pyzik M, See P, Glickman JN, Ginhoux F, Waldor M, Salmi M, Rantakari P, Blumberg RS. Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces. Nat Immunol. 2021 Jun;22(6):699-710. doi: 10.1038/s41590-021-00934-0. Epub 2021 May 26. PMID: 34040226; PMCID: PMC8171892.

June 8, 2021

Liwei Wang (Feske)

Guo, Y., Y. Q. Xie, M. Gao, Y. Zhao, F. Franco, M. Wenes, I. Siddiqui, A. Bevilacqua, H. Wang, H. Yang, B. Feng, X. Xie, C. M. Sabatel, B. Tschumi, A. Chaiboonchoe, Y. Wang, W. Li, W. Xiao, W. Held, P. Romero, P. C. Ho and L. Tang (2021). Metabolic reprogramming of terminally exhausted CD8(+) T cells by IL-10 enhances anti-tumor immunity. Nat Immunol. 2021 Jun;22(6):746-756.

June 1, 2021

Dhaval Dixit (Schwab)

Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, Loud M, Andolfo I, Patapoutian A. A role of PIEZO1 in iron metabolism in mice and humans. Cell. 2021 Feb 18;184(4):969-982.e13. doi: 10.1016/j.cell.2021.01.024. Epub 2021 Feb 10. PMID: 33571427; PMCID: PMC7927959.

Ying-Han Chen (Cadwell)

Gao X, Zhang D, Xu C, Li H, Caron KM, Frenette PS. Nociceptive nerves regulate haematopoietic stem cell mobilization. Nature. 2021 Jan;589(7843):591-596. doi: 10.1038/s41586-020-03057-y. Epub 2020 Dec 23. PMID: 33361809; PMCID: PMC7856173.

May 25, 2021

Ian Harvey (Littman)

Tomac J, Mazor M, Lisnić B, Golemac M, Kveštak D, Bralić M, Bilić Zulle L, Brinkmann MM, Dölken L, Reinert LS, Paludan SR, Krmpotić A, Jonjić S, Juranić Lisnić V. Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity. 2021 May 12:S1074-7613(21)00182-5. doi: 10.1016/j.immuni.2021.04.020. Epub ahead of print. PMID: 34015257.

Velmurugu Yogambigai (Krogsgaard)

Liu Y, Liu G, Wang J, Zheng ZY, Jia L, Rui W, Huang D, Zhou ZX, Zhou L, Wu X, Lin S, Zhao X, Lin X. Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors. Sci Transl Med. 2021 Mar 24;13(586):eabb5191. doi: 10.1126/scitranslmed.abb5191. PMID: 33762437.

May 18, 2021

Rabi Upadhyay (Littman)

Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE. Thymic development of gut-microbiota-specific T cells. Nature. 2021 May 12. doi: 10.1038/s41586-021-03531-1. Epub ahead of print. PMID: 33981034.

Lucile Noyer (Feske)

Kaczanowska S, Beury DW, Gopalan V, Tycko AK, Qin H, Clements ME, Drake J, Nwanze C, Murgai M, Rae Z, Ju W, Alexander KA, Kline J, Contreras CF, Wessel KM, Patel S, Hannenhalli S, Kelly MC, Kaplan RN. Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis. Cell. 2021 Apr 15;184(8):2033-2052.e21. doi: 10.1016/j.cell.2021.02.048. Epub 2021 Mar 24. PMID: 33765443.

May 11, 2021

Hernandez Moura Silva (Lafaille)

Chen ML, Huang X, Wang H, Hegner C, Liu Y, Shang J, Eliason A, Diao H, Park H, Frey B, Wang G, Mosure SA, Solt LA, Kojetin DJ, Rodriguez-Palacios A, Schady DA, Weaver CT, Pipkin ME, Moore DD, Sundrud MS. CAR directs T cell adaptation to bile acids in the small intestine. Nature. 2021 May;593(7857):147-151. doi: 10.1038/s41586-021-03421-6. Epub 2021 Apr 7. PMID: 33828301.

May 4, 2021

Taylor Heim (Lund)

Hochheiser K, Wiede F, Wagner T, Freestone D, Enders MH, Olshansky M, Russ B, Nüssing S, Bawden E, Braun A, Bachem A, Gressier E, McConville R, Park SL, Jones CM, Davey GM, Gyorki DE, Tscharke D, Parish IA, Turner S, Herold MJ, Tiganis T, Bedoui S, Gebhardt T. Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin. J Exp Med. 2021 Jun 7;218(6):e20200940. doi: 10.1084/jem.20200940. PMID: 33914023.

April 27, 2021

Yuelin Song (Littman)

Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 2021 Mar 26:S1931-3128(21)00131-1. doi: 10.1016/j.chom.2021.03.003. Epub ahead of print. PMID: 33798492.

Axel Concepcion (Feske)

Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W. The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol. 2021 Apr;22(4):460-470. doi: 10.1038/s41590-021-00888-3. Epub 2021 Mar 25. PMID: 33767425; PMCID: PMC8026726.

April 20, 2021

Lucie Bernard (Cadwell)

Drajac C, Laubreton D, Marquant Q, Chottin C, Ferret C, Bouguyon E, Schwartz-Cornil I, Saveanu L, Riffault S, Descamps D. Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection. Mucosal Immunol. 2021 Apr 12. doi: 10.1038/s41385-021-00402-w. Epub ahead of print. PMID: 33846534.

Boris Reizis

Motwani M, McGowan J, Antonovitch J, Gao KM, Jiang Z, Sharma S, Baltus GA, Nickerson KM, Marshak-Rothstein A, Fitzgerald KA. cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE. Front Immunol. 2021 Mar 29;12:605930. doi: 10.3389/fimmu.2021.605930. PMID: 33854495; PMCID: PMC8040952.

April 13, 2021

Tiger Wang (Feske)

Gonzalez-Figueroa P, Roco JA, Papa I, Núñez Villacís L, Stanley M, Linterman MA, Dent A, Canete PF, Vinuesa CG. Follicular regulatory T cells produce neuritin to regulate B cells. Cell. 2021 Apr 1;184(7):1775-1789.e19. doi: 10.1016/j.cell.2021.02.027. Epub 2021 Mar 11. PMID: 33711260.

Hao Xu (Littman)

Müller-Calleja N, Hollerbach A, Royce J, Ritter S, Pedrosa D, Madhusudhan T, Teifel S, Meineck M, Häuser F, Canisius A, Nguyen TS, Braun J, Bruns K, Etzold A, Zechner U, Strand S, Radsak M, Strand D, Gu JM, Weinmann-Menke J, Esmon CT, Teyton L, Lackner KJ, Ruf W. Lipid presentation by the protein C receptor links coagulation with autoimmunity. Science. 2021 Mar 12;371(6534):eabc0956. doi: 10.1126/science.abc0956. PMID: 33707237.

April 6, 2021

Anthony Tao (Feske)

Viant, C., G. H. J. Weymar, A. Escolano, S. Chen, H. Hartweger, M. Cipolla, A. Gazumyan, and M. C. Nussenzweig. 2020. Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates. Cell 183: 1298-1311.e11.

March 30, 2021

Nick Adams (Reizis)

Wijeyesinghe S, Beura LK, Pierson MJ, Stolley JM, Adam OA, Ruscher R, Steinert EM, Rosato PC, Vezys V, Masopust D. Expansible residence decentralizes immune homeostasis. Nature. 2021 Mar 17. doi: 10.1038/s41586-021-03351-3. Epub ahead of print. PMID: 33731934.

Kai Mesa (Littman)

Pfister D, et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature. 2021 Mar 24. doi: 10.1038/s41586-021-03362-0. Epub ahead of print. PMID: 33762733.

Dudek M, et al. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH. Nature. 2021 Mar 24. doi: 10.1038/s41586-021-03233-8. Epub ahead of print. PMID: 33762736.

March 23, 2021

Eugene Rudensky (Cadwell)

Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS. Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice. Science. 2021 Mar 12;371(6534):1154-1159. doi: 10.1126/science.abd0919. PMID: 33707263.

March 16, 2021

Lin Wu (Littman)

Wypych TP, Pattaroni C, Perdijk O, Yap C, Trompette A, Anderson D, Creek DJ, Harris NL, Marsland BJ. Microbial metabolism of L-tyrosine protects against allergic airway inflammation. Nat Immunol. 2021 Mar;22(3):279-286. doi: 10.1038/s41590-020-00856-3. Epub 2021 Jan 25. PMID: 33495652.

Ludovic Desvignes

Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, Horwitz MA, Liu J, Brooks DG. Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity. 2021 Mar 9;54(3):526-541.e7. doi: 10.1016/j.immuni.2021.01.003. Epub 2021 Jan 29. PMID: 33515487; PMCID: PMC7946746.

March 9, 2021

Tariq Najar (Littman)

Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA. T cell circuits that sense antigen density with an ultrasensitive threshold. Science. 2021 Mar 12;371(6534):1166-1171. doi: 10.1126/science.abc1855. Epub 2021 Feb 25. PMID: 33632893.

Ali Rashidfarrokhi (Papagiannakopoulos)

Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D, Kubes P. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science. 2021 Mar 5;371(6533):eabe0595. doi: 10.1126/science.abe0595. PMID: 33674464.

March 2, 2021

Ranit Kedmi (Littman)

Krienke C, Kolb L, Diken E, Streuber M, Kirchhoff S, Bukur T, Akilli-Öztürk Ö, Kranz LM, Berger H, Petschenka J, Diken M, Kreiter S, Yogev N, Waisman A, Karikó K, Türeci Ö, Sahin U. A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis. Science. 2021 Jan 8;371(6525):145-153. doi: 10.1126/science.aay3638. PMID: 33414215.

February 23, 2021

Varsha Raghavan (Littman)

Kiner E, Willie E, Vijaykumar B, Chowdhary K, Schmutz H, Chandler J, Schnell A, Thakore PI, LeGros G, Mostafavi S, Mathis D, Benoist C; Immunological Genome Project Consortium. Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes. Nat Immunol. 2021 Feb; 22(2): 216-228. doi: 10.1038/s41590-020-00836-7. Epub 2021 Jan 18. PMID: 33462454; PMCID: PMC7839314.

Jhimmy Talbot (Littman)

Aguilera-Lizarraga J, Florens MV, Viola MF, Jain P, Decraecker L, Appeltans I, Cuende-Estevez M, Fabre N, Van Beek K, Perna E, Balemans D, Stakenborg N, Theofanous S, Bosmans G, Mondelaers SU, Matteoli G, Ibiza Martínez S, Lopez-Lopez C, Jaramillo-Polanco J, Talavera K, Alpizar YA, Feyerabend TB, Rodewald HR, Farre R, Redegeld FA, Si J, Raes J, Breynaert C, Schrijvers R, Bosteels C, Lambrecht BN, Boyd SD, Hoh RA, Cabooter D, Nelis M, Augustijns P, Hendrix S, Strid J, Bisschops R, Reed DE, Vanner SJ, Denadai-Souza A, Wouters MM, Boeckxstaens GE. Local immune response to food antigens drives meal-induced abdominal pain. Nature. 2021 Feb;590(7844):151-156. doi: 10.1038/s41586-020-03118-2. Epub 2021 Jan 13. PMID: 33442055.

February 16, 2021

Oriana Perez (Reizis)

Huang S, Ziegler CGK, Austin J, Mannoun N, Vukovic M, Ordovas-Montanes J, Shalek AK, von Andrian UH. Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential. Cell. 2021 Jan 21;184(2):441-459.e25. doi: 10.1016/j.cell.2020.11.028. Epub 2020 Dec 16. PMID: 33333021.

Payal Damani-Yokota (Khanna)

Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments. Nat Immunol. 2021 Feb;22(2):179-192. doi: 10.1038/s41590-020-00848-3. Epub 2021 Jan 18. PMID: 33462452.

February 9, 2021

Christin Herrmann (Cadwell)

Becattini S, Sorbara MT, Kim SG, Littmann EL, Dong Q, Walsh G, Wright R, Amoretti L, Fontana E, Hohl TM, Pamer EG. Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Cell Host Microbe. 2021 Feb 2:S1931-3128(21)00033-0. doi: 10.1016/j.chom.2021.01.003. Epub ahead of print. PMID: 33539766.

Alice Kwon (Littman, Liddelow)

Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL  anti-inflammatory astrocytes. Nature. 2021 Jan 6. doi: 10.1038/s41586-020-03116-4. Epub ahead of print. PMID: 33408417.

February 2, 2021

Henry Nguyen (Littman)

Stacy A, Andrade-Oliveira V, McCulloch JA, Hild B, Oh JH, Perez-Chaparro PJ, Sim CK, Lim AI, Link VM, Enamorado M, Trinchieri G, Segre JA, Rehermann B, Belkaid Y. Infection trains the host for microbiota-enhanced resistance to pathogens. Cell. 2021 Jan 15:S0092-8674(20)31681-0. doi: 10.1016/j.cell.2020.12.011. Epub ahead of print. PMID: 33453153.

Xiaomin Yao (Cadwell)

Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Jan 27. doi: 10.1038/s41586-021-03231-w. Epub ahead of print. PMID: 33505023.

January 26, 2021

Joe Pucella (Reizis)

Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021 Jan 18. doi: 10.1038/s41586-021-03207-w. Epub ahead of print. PMID: 33461210.

January 19, 2021

Doua Azzouz (Silverman)

Woodruff, M.C., Ramonell, R.P., Nguyen, D.C. et al. Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19. Nat Immunol 21, 1506–1516 (2020).

January 12, 2021

Ying-Han Chen (Cadwell)

Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD. Galactosaminogalactan activates the inflammasome to provide host protection. Nature. 2020 Dec; 588(7839):688-692.

Lucile Noyer (Feske)

Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nat Med. 2021 Jan 4. doi: 10.1038/s41591-020-1131-x. Epub ahead of print. PMID: 33398162.

January 5, 2021

Liwei Wang (Feske)

Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO. TGF-β suppresses type 2 immunity to cancer. Nature. 2020 Nov; 587(7832): 115-120.  

Ian Harvey (Littman)

Verma, V., Jafarzadeh, N., Boi, S. et al. MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects. Nat Immunol 22, 53–66 (2021).

December 15, 2020

Simone Dallari (Cadwell)

Fluckiger A, Daillère R, Sassi M, Sixt BS, Liu P, Loos F, Richard C, Rabu C, Alou MT, Goubet AG, Lemaitre F, Ferrere G, Derosa L, Duong CPM, Messaoudene M, Gagné A, Joubert P, De Sordi L, Debarbieux L, Simon S, Scarlata CM, Ayyoub M, Palermo B, Facciolo F, Boidot R, Wheeler R, Boneca IG, Sztupinszki Z, Papp K, Csabai I, Pasolli E, Segata N, Lopez-Otin C, Szallasi Z, Andre F, Iebba V, Quiniou V, Klatzmann D, Boukhalil J, Khelaifia S, Raoult D, Albiges L, Escudier B, Eggermont A, Mami-Chouaib F, Nistico P, Ghiringhelli F, Routy B, Labarrière N, Cattoir V, Kroemer G, Zitvogel L. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Science. 2020 Aug 21; 369(6506): 936-942.  

Yuelin Song (Littman)

Msallam R, Balla J, Rathore APS, Kared H, Malleret B, Saron WAA, Liu Z, Hang JW, Dutertre CA, Larbi A, Chan JKY, St John AL, Ginhoux F. Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. Science. 2020 Nov 20; 370(6519): 941-950.

December 8, 2020

Velmurugu Yogambigai (Krogsgaard)

Evnouchidou I, Chappert P, Benadda S, Zucchetti A, Weimershaus M, Bens M, Caillens V, Koumantou D, Lotersztajn S, van Endert P, Davoust J, Guermonprez P, Hivroz C, Gross DA, Saveanu L. IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses. Nat Commun. 2020 Jun 2; 11(1): 2779. doi: 10.1038/s41467-020-16471-7. PMID: 32487999; PMCID: PMC7265453.

Hernandez Moura Silva (Lafaille)

Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL Jr, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Cell Metab. 2020 Nov 26:S1550-4131(20)30603-3. doi: 10.1016/j.cmet.2020.11.008. Epub ahead of print. PMID: 33278339.

December 1, 2020

Axel Concepcion (Feske)

Yu CH, Davidson S, Harapas CR, Hilton JB, Mlodzianoski MJ, Laohamonthonkul P, Louis C, Low RRJ, Moecking J, De Nardo D, Balka KR, Calleja DJ, Moghaddas F, Ni E, McLean CA, Samson AL, Tyebji S, Tonkin CJ, Bye CR, Turner BJ, Pepin G, Gantier MP, Rogers KL, McArthur K, Crouch PJ, Masters SL. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Cell. 2020 Oct 29; 183(3):636-649.e18. doi: 10.1016/j.cell.2020.09.020. Epub 2020 Oct 7. PMCID: PMC7599077.

November 24, 2020

Rabi Upadhyay (Littman)

Stefan KL, Kim MV, Iwasaki A, Kasper DL. Commensal Microbiota Modulation of Natural Resistance to Virus Infection. Cell. 2020 Nov 13: S0092-8674(20)31454-9.

November 17, 2020

Lucie Bernard (Cadwell)

Al Rumaih Z, Tuazon Kels MJ, Ng E, Pandey P, Pontejo SM, Alejo A, Alcamí A, Chaudhri G, Karupiah G. Poxvirus-encoded TNF receptor homolog dampens inflammation and protects from uncontrolled lung pathology during respiratory infection. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26885-26894. doi: 10.1073/pnas.2004688117. Epub 2020 Oct 12. PMID: 33046647

November 10, 2020

Tiger Wang (Feske)

Chang D, Xing Q, Su Y, Zhao X, Xu W, Wang X, Dong C. The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. Immunity. 2020 Sep 15; 53(3): 614-626.e4. doi: 10.1016/j.immuni.2020.07.012. Epub 2020 Aug 21. PMID: 32827457.

June-Yong Lee (Littman)

Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. Immune receptor inhibition through enforced phosphatase recruitment. Nature. 2020 Oct; 586(7831): 779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21. PMID: 33087934.

November 3, 2020

Anthony Tao (Feske)

Weisel, F. J., S. J. Mullett, R. A. Elsner, A. V. Menk, N. Trivedi, W. Luo, D. Wikenheiser, W. F. Hawse, M. Chikina, S. Smita, L. J. Conter, S. M. Joachim, S. G. Wendell, M. J. Jurczak, T. H. Winkler, G. M. Delgoffe, and M. J. Shlomchik. 2020. Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis. Nature Immunology 21: 331–342.

Hao Xu (Littman)

Guo H, Chou WC, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020 Oct 30; 370(6516): eaay9097.

October 27, 2020

Kai Mesa (Littman)

Li Y, He X, Kawaguchi R, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich PG, Geschwind DH, He Z. Microglia-organized scar-free spinal cord repair in neonatal mice. Nature. 2020 Oct 7. doi: 10.1038/s41586-020-2795-6. Epub ahead of print. PMID: 33029008.

Audrey Baeyens (Schwab)

Caroline Perner, Cameron H. Flayer, Xueping Zhu, Pamela A. Aderhold, Zaynah N.A. Dewan, Tiphaine Voisin, Ryan B. Camire, Ohn A. Chow, Isaac M. Chiu, and Caroline L. Sokol. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. 2020 Oct 23.

October 20, 2020

Nick Adams (Reizis)

The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells. Miyazaki K, Watanabe H, Yoshikawa G, Chen K, Hidaka R, Aitani Y, Osawa K, Takeda R, Ochi Y, Tani-Ichi S, Uehata T, Takeuchi O, Ikuta K, Ogawa S, Kondoh G, Lin YC, Ogata H, Miyazaki M. Sci Immunol. 2020 Sep 4; 5(51):eabb1455. doi: 10.1126/sciimmunol.abb1455. PMID: 32887843

Juan Lafaille

Berglund R, Guerreiro-Cacais AO, Adzemovic MZ, Zeitelhofer M, Lund H, Ewing E, Ruhrmann S, Nutma E, Parsa R, Thessen-Hedreul M, Amor S, Harris RA, Olsson T, Jagodic M. Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation. Sci Immunol. 2020 Oct 16; 5(52):eabb5077. doi: 10.1126/sciimmunol.abb5077. PMID: 33067381.

October 13, 2020

Eugene Rudensky (Cadwell)

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection. Maximillian S. Habibi, Ryan S. Thwaites, Meiping Chang, Agnieszka Jozwik, Allan Paras, Freja Kirsebom, Augusto Varese, Amber Owen, Leah Cuthbertson, Phillip James, Tanushree Tunstall, David Nickle, Trevor T. Hansel, Miriam F. Moffatt, Cecilia Johansson, Christopher Chiu, Peter J. M. Openshaw. Science 09 Oct 2020

October 6, 2020

Lin Wu (Littman)

Chikina AS, Nadalin F, Maurin M, San-Roman M, Thomas-Bonafos T, Li XV, Lameiras S, Baulande S, Henri S, Malissen B, Lacerda Mariano L, Barbazan J, Blander JM, Iliev ID, Matic Vignjevic D, Lennon-Duménil AM. Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption. Cell. 2020 Sep 17: S0092-8674(20)31090-4. doi: 10.1016/j.cell.2020.08.048. Epub ahead of print. PMID: 32970988.

Ali Rashidfarrokhi (Papagiannakopoulos)

Li P, Lu M, Shi J, Gong Z, Hua L, Li Q, Lim B, Zhang XH, Chen X, Li S, Shultz LD, Ren G. Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nat Immunol. 2020 Sep 21. doi: 10.1038/s41590-020-0783-5. Epub ahead of print. PMID: 32958928.

September 29, 2020

Tariq Najar (Littman)

Harbour SN, DiToro DF, Witte SJ, Zindl CL, Gao M, Schoeb TR, Jones GW, Jones SA, Hatton RD, Weaver CT. TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Sci Immunol. 2020 Jul 17; 5(49): eaaw2262. doi: 10.1126/sciimmunol.aaw2262. PMID: 32680955.

September 22, 2020

Ranit Kedmi (Littman)

Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, Yshii L, Martinez-Muriana A, Naughton M, Young A, Moudra A, Lemaitre P, Poovathingal S, Raes J, De Strooper B, Fitzgerald DC, Dooley J, Liston A. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020 Aug 6; 182(3):625-640.e24. doi: 10.1016/j.cell.2020.06.026. Epub 2020 Jul 22. PMID: 32702313; PMCID: PMC7427333.

Yue Xing (Naik)

Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A. A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell. 2020 Sep 9:S0092-8674(20)31073-4. doi: 10.1016/j.cell.2020.08.031. Epub ahead of print. PMID: 32937105.

September 15, 2020

Payal Damani-Yokota (Khanna)

Neupane AS, Willson M, Chojnacki AK, Vargas E Silva Castanheira F, Morehouse C, Carestia A, Keller AE, Peiseler M, DiGiandomenico A, Kelly MM, Amrein M, Jenne C, Thanabalasuriar A, Kubes P. Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis. Cell. 2020 Aug 31: S0092-8674(20)31011-4. doi: 10.1016/j.cell.2020.08.020. Epub ahead of print. PMID: 32888431.

Jhimmy Talbot (Littman)

Tuganbaev T, Mor U, Bashiardes S, Liwinski T, Nobs SP, Leshem A, Dori-Bachash M, Thaiss CA, Pinker EY, Ratiner K, Adlung L, Federici S, Kleimeyer C, Moresi C, Yamada T, Cohen Y, Zhang X, Massalha H, Massasa E, Kuperman Y, Koni PA, Harmelin A, Gao N, Itzkovitz S, Honda K, Shapiro H, Elinav E. Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis. Cell. 2020 Sep 2: S0092-8674(20)31069-2. doi: 10.1016/j.cell.2020.08.027. Epub ahead of print. PMID: 32888430.

September 8, 2020

Varsha Raghavan (Littman)

McCauley ME, O'Rourke JG, Yáñez A, Markman JL, Ho R, Wang X, Chen S, Lall D, Jin M, Muhammad AKMG, Bell S, Landeros J, Valencia V, Harms M, Arditi M, Jefferies C, Baloh RH. C9orf72 in myeloid cells suppresses STING-induced inflammation. Nature. 2020 Sep; 585(7823):96-101. doi: 10.1038/s41586-020-2625-x. Epub 2020 Aug 19. PMID: 32814898.

September 1, 2020

Alice Kwon (Littman, Liddelow)

Muller PA, Matheis F, Schneeberger M, Kerner Z, Jové V, Mucida D. Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose [published online ahead of print, 2020 Aug 27]. Science. 2020; eabd6176. doi:10.1126/science.abd6176

Christin Herrmann (Cadwell)

Liu X, Boyer MA, Holmgren AM, Shin S. Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation [published online ahead of print, 2020 Aug 20]. Cell Host Microbe. 2020; S1931-3128(20)30422-4. doi:10.1016/j.chom.2020.07.019

August 25, 2020

Henry Nguyen (Littman)

Mager LF, Burkhard R, Pett N, et al. Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy [published online ahead of print, 2020 Aug 13]. Science. 2020; eabc3421. doi:10.1126/science.abc3421

Xiaomin Yao (Cadwell)

Joanne Durgan, Alf H. Lystad, Katherine Sloan, Sven R. Carlsson, Michael I. Wilson, Elena Marcassa, Rachel Ulferts, Judith Webster, Andrea F. Lopez-Clavijo, Michael J. Wakelam, Rupert Beale, Anne Simonsen, David Oxley, Oliver Florey (2020) Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine. bioRxiv 2020.05.14.096115; doi: https://doi.org/10.1101/2020.05.14.096115

August 18, 2020

Joe Pucella (Reizis)

Israelow B, Song E, Mao T, et al. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. J Exp Med. 2020; 217(12):e20201241. doi:10.1084/jem.20201241

Dhaval Dixit (Schwab)

Amor, C., Feucht, J., Leibold, J. et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 583, 127–132 (2020).

August 11, 2020

Patrícia D'Emery Alves Santos (Lafaille)

Kadosh E, Snir-Alkalay I, Venkatachalam A, et al. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic [published online ahead of print, 2020 Jul 29]. Nature. 2020; 10.1038/s41586-020-2541-0. doi:10.1038/s41586-020-2541-0

Doua Azzouz (Silverman)

Tanaka S, Ise W, Inoue T, et al. Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. Nat Immunol. 2020; 21(8):950-961. doi:10.1038/s41590-020-0700-y

August 4, 2020

Ying-Han Chen (Cadwell)

Zhou QD, Chi X, Lee MS, et al. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020;21(7):746-755. doi:10.1038/s41590-020-0695-4

Lucile Noyer (Feske)

Lai, J., Mardiana, S., House, I.G. et al. Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity. Nat Immunol 21, 914–926 (2020).

July 28, 2020

Simone Dallari (Cadwell)

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Alexander J. Meeske, Ning Jia, Alice K. Cassel, Albina Kozlova, Jingqiu Liao, Martin Wiedmann, Dinshaw J. Patel, Luciano A. Marraffini. Science 03 Jul 2020: 54-59

Liwei Wang (Feske)

Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. (2020) Shivashankar Othy, Amit Jairaman, Joseph L. Dynes, Tobias X. Dong, Cornelia Tune, Andriy V. Yeromin, Angel Zavala, Chijioke Akunwafo, Fangyi Chen, Ian Parker, Michael D. Cahalan. Forthcoming in PNAS

July 21, 2020

Hernandez Moura Silva (Lafaille)

Qing H, Desrouleaux R, Israni-Winger K, et al. Origin and Function of Stress-Induced IL-6 in Murine Models [published online ahead of print, 2020 Jun 27]. Cell. 2020;S0092-8674(20)30687-5. doi:10.1016/j.cell.2020.05.054

July 14, 2020

Axel Concepcion (Feske)

Wang H, Franco F, Tsui YC, et al. CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors. Nat Immunol. 2020 Mar; 21(3):298-308.  doi: 10.1038/s41590-019-0589-5.

Ioanna Tiniakou (Reizis)

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.Jianjun Wu, Nicole Dobbs, Kun Yang, Nan Yan;Immunity. 2020 Jul 2; S1074-7613(20)30264-8.

July 7, 2020

Boris Reizis

Kamitaki N, Sekar A, Handsaker RE, et al. Complement genes contribute sex-biased vulnerability in diverse disorders. Nature. 2020; 582(7813):577-581. doi:10.1038/s41586-020-2277-x

June 30, 2020

Jessica Neil (Cadwell)

Smole U, Gour N, Phelan J, et al. Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity. Nat Immunol. 2020; 21(7):756-765. doi:10.1038/s41590-020-0698-1

Rabi Upadhyay (Littman)

Campbell C, McKenney PT, Konstantinovsky D, et al. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020; 581(7809):475-479. doi:10.1038/s41586-020-2193-0

June 23, 2020

Tiger Wang (Feske)

Bálint, Müller S, Fischer R, et al. Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells. Science. 2020; 368(6493):897-901. doi: 10.1126/science.aay9207

Ken Cadwell

Sho Kitamoto, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G. Gillilland III, Atsushi Hayashi, Jin Imai, Kohei Sugihara, Mao Miyoshi, Jennifer C. Brazil, Peter Kuffa, Brett D. Hill, Syed M. Rizvi, Fei Wen, Shrinivas Bishu, Naohiro Inohara, Kathryn A. Eaton, Asma Nusrat, Yu L. Lei, William V. Giannobile, Nobuhiko Kamada. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell. June 16, 2020. doi: 10.1016/j.cell.2020.05.048

June 16, 2020

Tony Tao (Feske)

Berry, C. T., X. Liu, A. Myles, S. Nandi, Y. H. Chen, U. Hershberg, I. E. Brodsky, M. P. Cancro, C. J. Lengner, M. J. May, and B. D. Freedman. 2020. BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Rep 31: 107474.

June 9, 2020

Audrey Baeyens (Schwab)

Dai H, Lan P, Zhao D, et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science. 2020; 368(6495):1122‐1127. doi:10.1126/science.aax4040

Hao Xu (Littman)

Zeyu Chen, Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He, HuaHuang, Sasikanth Manne, Zhendong Cao, Amy E. Baxter, Zhangying Cai, ElizabethFreilich, Mohammed A. Ali, Josephine R. Giles, Jennifer E. Wu, Allison R. Greenplate, Makoto Kurachi, Kito Nzingha, Viktoriya Ekshyyan, Zhuoyu Wen, Nancy A. Speck, Alexis Battle, Shelley L. Berger, E. John Wherry, Junwei Shi. (2020) In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer. bioRxiv 2020.05.20.087379

June 2, 2020

Ali Rashidfarrokhi (Papagiannakopoulos)

Maier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D'Amore NR, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020 Apr; 580(7802): 257-262. doi: 10.1038/s41586-020-2134-y. Epub 2020 Mar 25. PMID: 32269339.

Kai Mesa (Littman)

Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, Rooze P, Broquet A, Misme-Aucouturier B, Chaumette T, Vourc'h M, Cinotti R, Marec N, Gauttier V, McWilliam HEG, Altare F, Poschmann J, Villadangos JA, Asehnoune K. Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis. Nat Immunol. 2020 Jun; 21(6): 636-648. doi: 10.1038/s41590-020-0673-x. Epub 2020 May 18. PMID: 32424365.

May 26, 2020

Nick Adams (Reizis)

Schaupp L, Muth S, Rogell L, et al. Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells [published online ahead of print, 2020 May 3]. Cell. 2020; S0092-8674(20)30485-2. doi:10.1016/j.cell.2020.04.022

May 19, 2020

Eugene Rudensky (Cadwell)

De Giovanni, M., Cutillo, V., Giladi, A. et al. Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells. Nat Immunol 21, 321–330 (2020).

May 12, 2020

Lin Wu (Littman)

Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 May; 581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22. PubMed PMID: 32376951.

Ludovic Desvignes

Development of an inactivated vaccine candidate for SARS-CoV-2 by Qiang Gao et al., Science (published online 06 MAY 2020). DOI: 10.1126/science.abc1932

May 5, 2020

Yue Xing (Naik)

Caleb A. Dawson,Bhupinder Pal, François Vaillant,Luke C. Gandolfo,Zhaoyuan Liu,Camille Bleriot,Florent Ginhoux,Gordon K. Smyth,Geoffrey J. Lindeman,Scott N. Mueller,Anne C. Rios, Jane E. Visvader(2020) Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.Nat Cell Biol(2020).

Tariq Najar (Littman)

Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH. CRISPR-engineered T cells in patients with refractory cancer. Science. 2020 Feb 28; 367(6481). pii: eaba7365. doi: 10.1126/science.aba7365. Epub 2020 Feb 6. PubMed PMID: 32029687.

April 28, 2020

Oriana Perez (Reizis)

Koscsó B, Kurapati S, Rodrigues RR, Nedjic J, Gowda K, Shin C, Soni C, Ashraf AZ, Purushothaman I, Palisoc M, Xu S, Sun H, Chodisetti SB, Lin E, Mack M, Kawasawa YI, He P, Rahman ZSM, Aifantis I, Shulzhenko N, Morgun A, Bogunovic M. Gut-resident CX3CR1(hi) macrophages induce tertiary lymphoid structures and IgA response in situ. Sci Immunol. 2020 Apr 10; 5(46). pii: eaax0062. doi: 10.1126/sciimmunol.aax0062. PubMed PMID: 32276965.

Payal Damani-Yokota (Khanna)

Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen-Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Møller, Tristan X. Jordan, Kohei Oishi, Maryline Panis, David Sachs, Taia T. Wang, Robert E. Schwartz, Jean K. Lim, Randy A. Albrecht, Benjamin R. tenOever (2020) Imbalanced host response to SARS-CoV-2 drives development of COVID-19.Cell Press Coronavirus Resource Hub

April 21, 2020

Jhimmy Talbot (Littman)

Bessman NJ, Mathieu JRR, Renassia C, Zhou L, Fung TC, Fernandez KC, Austin C, Moeller JB, Zumerle S, Louis S, Vaulont S, Ajami NJ, Sokol H, Putzel GG, Arvedson T, Sockolow RE, Lakhal-Littleton S, Cloonan SM, Arora M, Peyssonnaux C, Sonnenberg GF. Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science. 2020 Apr 10; 368(6487):186-189.

Ranit Kedmi (Littman)

Hong JY, Lim J, Carvalho F, Cho JY, Vaidyanathan B, Yu S, Annicelli C, Ip WKE, Medzhitov R. Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. Cell. 2020 Mar 5; 180(5):847-861.e15. doi: 10.1016/j.cell.2020.02.018. PubMed PMID: 32142678.

April 14, 2020

Varsha Raghavan (Littman)

Si Y, Zhao F, Beesetty P, Weiskopf D, Li Z, Tian Q, Alegre ML, Sette A, Chong AS, Montgomery CP. Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination. Sci Adv. 2020 Apr 1; 6(14): eaaw7713. doi: 10.1126/sciadv.aaw7713. eCollection 2020 Apr. PubMed PMID: 32270029; PubMed Central PMCID: PMC7112766.

Xiaomin Yao (Cadwell)

Ruicong Wang, Hongda Li, Jianfeng Wu, Zhi-Yu Cai, Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han, Wei Mo. Gut stem cell necroptosis by genome instability triggers bowel inflammation. Nature (25 March 2020)

April 7, 2020

Christin Herrmann (Cadwell)

Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 Dec 11;26(6):795-809.e5. doi: 10.1016/j.chom.2019.10.007. Epub 2019 Nov 26. PubMed PMID: 31784259; PubMed Central PMCID: PMC6989301.

Alice Kwon (Littman, Liddelow)

Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer, Juan Lin, Remzi Onur Eren, Amanda Fisher, Rebecca Lane, George R. Young, George Kassiotis, William J. Kaiser, Manolis Pasparakis (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature (25 March 2020)

March 31, 2020

Dhaval Dixit (Schwab)

Medina, C.B., Mehrotra, P., Arandjelovic, S., Perry, J.S.A., Guo, Y., Morioka, S., Barron, B., Walk, S.F., Ghesquiere, B., Krupnick, A.S., Lorenz, U., Ravichandran, K.S. Metabolites released from apoptotic cells act as tissue messengers. Nature (March 18, 2020).

March 24, 2020

Patrícia D'Emery Alves Santos (Lafaille)

Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 Feb;578(7796):610-614. doi: 10.1038/s41586-020-2028-z. Epub 2020 Feb 19. PubMed PMID: 32076265; PubMed Central PMCID: PMC7055484.

Doua Azzouz (Silverman)

James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA. Distinct microbial and immune niches of the human colon. Nat Immunol. 2020 Mar;21(3):343-353. doi: 10.1038/s41590-020-0602-z. Epub 2020 Feb 17. PubMed PMID: 32066951.

March 17, 2020

Ying-Han Chen (Cadwell)

Obata Y, Castaño Á, Boeing S, Bon-Frauches AC, Fung C, Fallesen T, de Agüero MG, Yilmaz B, Lopes R, Huseynova A, Horswell S, Maradana MR, Boesmans W, Vanden Berghe P, Murray AJ, Stockinger B, Macpherson AJ, Pachnis V. Neuronal programming by microbiota regulates intestinal physiology. Nature. 2020 Feb;578(7794):284-289. doi: 10.1038/s41586-020-1975-8. Epub 2020 Feb 5. PubMed PMID: 32025031.

March 10, 2020

Liwei Wang (Feske)

Zhou Y, Fei M, Zhang G, Liang WC, Lin W, Wu Y, Piskol R, Ridgway J, McNamara E, Huang H, Zhang J, Oh J, Patel JM, Jakubiak D, Lau J, Blackwood B, Bravo DD, Shi Y, Wang J, Hu HM, Lee WP, Jesudason R, Sangaraju D, Modrusan Z, Anderson KR, Warming S, Roose-Girma M, Yan M. Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP. Immunity. 2020 Feb 18;52(2):357-373.e9. doi: 10.1016/j.immuni.2020.01.014. Epub 2020 Feb 11. PubMed PMID: 32049051. 

Simone Dallari (Cadwell)

Liu Y, Nguyen PT, Wang X, Zhao Y, Meacham CE, Zou Z, Bordieanu B, Johanns M, Vertommen D, Wijshake T, May H, Xiao G, Shoji-Kawata S, Rider MH, Morrison SJ, Mishra P, Levine B. TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise. Nature. 2020 Feb;578(7796):605-609. doi: 10.1038/s41586-020-1992-7. Epub 2020 Feb 12. PubMed PMID: 32051584; PubMed Central PMCID: PMC7047589.

March 3, 2020

Aswin Natarajan (Krogsgaard)

Crowther MD, Dolton G, Legut M, Caillaud ME, Lloyd A, Attaf M, Galloway SAE, Rius C, Farrell CP, Szomolay B, Ager A, Parker AL, Fuller A, Donia M, McCluskey J, Rossjohn J, Svane IM, Phillips JD, Sewell AK. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nat Immunol. 2020 Feb;21(2):178-185. doi: 10.1038/s41590-019-0578-8. Epub 2020 Jan 20. PubMed PMID: 31959982; PubMed Central PMCID: PMC6983325. 

Hernandez Moura Silva (Lafaille)

Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Torres SV, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A. Sex-specific adipose tissue imprinting of regulatory T cells. Nature. 2020 Feb 26. doi: 10.1038/s41586-020-2040-3. [Epub ahead of print] PubMed PMID: 32103173.

February 25, 2020

Yu Matsuzawa (Cadwell)

Bitton A, Avlas S, Reichman H, Itan M, Karo-Atar D, Azouz NP, Rozenberg P, Diesendruck Y, Nahary L, Rothenberg ME, Benhar I, Munitz A. A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Sci Immunol. 2020 Feb 14;5(44). pii: eaaw2938. doi: 10.1126/sciimmunol.aaw2938. PubMed PMID: 32060143.

February 18, 2020

Susan Schwab

Eric Song, Tianyang Mao, Huiping Dong, Ligia Simoes Braga Boisserand, Salli Antila, Marcus Bosenberg, Kari Alitalo, Jean-Leon Thomas & Akiko Iwasaki. (2020) VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours. Nature volume 577, pages 689-694

Ioanna Tiniakou (Reizis)

Strauss L, Mahmoud MAA, Weaver JD, Tijaro-Ovalle NM, Christofides A, Wang Q, Pal R, Yuan M, Asara J, Patsoukis N, Boussiotis VA. (2020) Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Sci Immunol. 5(43).

February 11, 2020

Boris Reizis

Kim J, Gupta R, Blanco LP, Yang S, Shteinfer-Kuzmine A, Wang K, Zhu J, Yoon HE, Wang X, Kerkhofs M, Kang H, Brown AL, Park SJ, Xu X, Zandee van Rilland E, Kim MK, Cohen JI, Kaplan MJ, Shoshan-Barmatz V, Chung JH. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science. 2019 Dec 20; 366(6472): 1531-1536. doi: 10.1126/science.aav4011. Epub 2019 Dec 19. PubMed PMID: 31857488.

Axel Concepcion (Feske)

McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG. Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity. 2020 Jan 27. pii: S1074-7613(20)30029-7. doi: 10.1016/j.immuni.2020.01.002. [Epub ahead of print] PubMed PMID: 32023490.

January 28, 2020

Matt Keller (Cadwell)

Jain A, Irizarry-Caro RA, McDaniel MM, Chawla AS, Carroll KR, Overcast GR, Philip NH, Oberst A, Chervonsky AV, Katz JD, Pasare C. T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity. Nat Immunol. 2020 Jan;21(1):65-74. doi: 10.1038/s41590-019-0559-y. Epub 2019 Dec 17. PubMed PMID: 31848486; PubMed Central PMCID: PMC6927526.

Tiger Wang (Feske)

Zhao R, Chen X, Ma W, Zhang J, Guo J, Zhong X, Yao J, Sun J, Rubinfien J, Zhou X, Wang J, Qi H. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature. 2020 Jan;577(7790):416-420. doi: 10.1038/s41586-019-1873-0. Epub 2019 Dec 25. PubMed PMID: 31875850.

January 21, 2020

Jessica Neil (Cadwell)

Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel EM, Mack M, Beinke S, Wack A. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat Immunol. 2020 Jan 13. doi: 10.1038/s41590-019-0568-x. [Epub ahead of print] PubMed PMID: 31932810.

Hao Xu (Littman)

Cabrita R, Lauss M, Sanna A, Donia M, Skaarup Larsen M, Mitra S, Johansson I, Phung B, Harbst K, Vallon-Christersson J, van Schoiack A, Lövgren K, Warren S, Jirström K, Olsson H, Pietras K, Ingvar C, Isaksson K, Schadendorf D, Schmidt H, Bastholt L, Carneiro A, Wargo JA, Svane IM, Jönsson G. Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature. 2020 Jan 15. doi: 10.1038/s41586-019-1914-8. [Epub ahead of print] PubMed PMID: 31942071.

January 14, 2020

Hannah Fehlner-Peach (Littman)

Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. Microbial bile acid metabolites modulate gut RORγ(+) regulatory T cell homeostasis. Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1865-0. [Epub ahead of print] PubMed PMID: 31875848.

Juan Lafaille

Reed MD, Yim YS, Wimmer RD, Kim H, Ryu C, Welch GM, Andina M, King HO, Waisman A, Halassa MM, Huh JR, Choi GB. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2020 Jan;577(7789):249-253. doi: 10.1038/s41586-019-1843-6. Epub 2019 Dec 18. PubMed PMID: 31853066.

January 7, 2020

Audrey Baeyens (Schwab)

Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019 Dec;576(7787):471-476. doi: 10.1038/s41586-019-1821-z. Epub 2019 Dec 11. PubMed PMID: 31827283; PubMed Central PMCID: PMC6937596.

December 17, 2019

Ali Rashidfarrohki (Papagiannakopoulos)

Radermecker C, Sabatel C, Vanwinge C, Ruscitti C, Maréchal P, Perin F, Schyns J, Rocks N, Toussaint M, Cataldo D, Johnston SL, Bureau F, Marichal T. Locally instructed CXCR4(hi) neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps. Nat Immunol. 2019 Nov;20(11):1444-1455. doi: 10.1038/s41590-019-0496-9. Epub 2019 Oct 7. PubMed PMID: 31591573; PubMed Central PMCID: PMC6859073.

Kai Mesa (Littman)

Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AK, Schwanekamp JA, York AJ, Huang V, Nahrendorf M, Sadayappan S, Molkentin JD. An acute immune response underlies the benefit of cardiac stem-cell therapy. Nature. 2019 Nov 27. doi: 10.1038/s41586-019-1802-2. [Epub ahead of print] PubMed PMID: 31775156.

December 10, 2019

Patricia Martin (Cadwell)

Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S. 2019. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science: eaaw9544

December 3, 2019

Eugene Rudensky (Cadwell)

Chun E, Lavoie S, Fonseca-Pereira D, Bae S, Michaud M, Hoveyda HR, Fraser GL, Gallini Comeau CA, Glickman JN, Fuller MH, Layden BT, Garrett WS. Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity. Immunity. 2019 Nov 19;51(5):871-884.e6. doi: 10.1016/j.immuni.2019.09.014. Epub 2019 Oct 15. PubMed PMID: 31628054.

June-Yong Lee (Littman)

Jiao S, Subudhi SK, Aparicio A, Ge Z, Guan B, Miura Y, Sharma P. Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy. Cell. 2019 Nov 14;179(5):1177-1190.e13. doi: 10.1016/j.cell.2019.10.029. PubMed PMID: 31730856.

November 26, 2019

Lin Wu (Littman)

Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019 Nov 7. pii: eaav2588. doi: 10.1126/science.aav2588. [Epub ahead of print] PubMed PMID: 31699883.

Ludovic Desvignes

Petrova VN, Sawatsky B, Han AX, Laksono BM, Walz L, Parker E, Pieper K, Anderson CA, de Vries RD, Lanzavecchia A, Kellam P, von Messling V, de Swart RL, Russell CA. Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles. Sci Immunol. 2019 Nov 1;4(41). pii: eaay6125. doi: 10.1126/sciimmunol.aay6125. PubMed PMID: 31672862.

November 19, 2019

Yue Xing (Naik)

Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nat Immunol. 2019 Oct 21. doi: 10.1038/s41590-019-0513-z. [Epub ahead of print] PubMed PMID: 31636462. 

Varsha Raghavan (Littman)

Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. 2019. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity 51, Nov. 19, 2019

November 12, 2019

Oriana Perez (Reizis)

Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR. Migratory DCs activate TGF-β to precondition naïve CD8(+) T cells for tissue-resident memory fate. Science. 2019 Oct 11;366(6462). pii: eaav5728. doi: 10.1126/science.aav5728. PubMed PMID: 31601741.

Payal Damani-Yokota (Khanna)

Ichikawa T, Hirahara K, Kokubo K, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes DJ, Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T. CD103(hi) T(reg) cells constrain lung fibrosis induced by CD103(lo) tissue-resident pathogenic CD4 T cells. Nat Immunol. 2019 Oct 7. doi: 10.1038/s41590-019-0494-y. [Epub ahead of print] PubMed PMID: 31591568.

November 5, 2019

Jhimmy Talbot (Littman)

Johnston RJ, Su LJ, Pinckney J, Critton D, Boyer E, Krishnakumar A, Corbett M, Rankin AL, Dibella R, Campbell L, Martin GH, Lemar H, Cayton T, Huang RY, Deng X, Nayeem A, Chen H, Ergel B, Rizzo JM, Yamniuk AP, Dutta S, Ngo J, Shorts AO, Ramakrishnan R, Kozhich A, Holloway J, Fang H, Wang YK, Yang Z, Thiam K, Rakestraw G, Rajpal A, Sheppard P, Quigley M, Bahjat KS, Korman AJ. VISTA is an acidic pH-selective ligand for PSGL-1. Nature. 2019 Oct;574(7779):565-570. doi:10.1038/s41586-019-1674-5. Epub 2019 Oct 23. PubMed PMID: 31645726.

Taz Samji (Khanna)

Zou F, Lu L, Liu J, Xia B, Zhang W, Hu Q, Liu W, Zhang Y, Lin Y, Jing S, Huang M, Huang B, Liu B, Zhang H. Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56. Nat Commun. 2019 Sep 11;10(1):4109. doi: 10.1038/s41467-019-11893-4. PubMed PMID: 31511513; PubMed Central PMCID: PMC6739330.

October 22, 2019

Xiaomin Yao (Cadwell)

Motoko Koyama, Pamela Mukhopadhyay, Iona S. Schuster, Andrea S. Henden, Jan Hülsdünker, Antiopi Varelias, Marie Vetizou, Rachel D. Kuns, Renee J. Robb, Ping Zhang, Bruce R. Blazar, Ranjeny Thomas, Jakob Begun, Nicola Waddell, Giorgio Trinchieri, Robert Zeiser, Andrew D. Clouston, Mariapia A. Degli-Esposti, and Geoffrey R. Hill. MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota. Immunity. 2019 Sep 18. pii: S1074-7613(19)30362-0. doi: 10.1016/j.immuni.2019.08.011. PMID: 31542340.

Tariq Najar (Littman)

Legoux F, Bellet D, Daviaud C, El Morr Y, Darbois A, Niort K, Procopio E, Salou M, Gilet J, Ryffel B, Balvay A, Foussier A, Sarkis M, El Marjou A, Schmidt F, Rabot S, Lantz O. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Science. 2019 Aug 29. pii: eaaw2719. doi: 10.1126/science.aaw2719. [Epub ahead of print] PubMed PMID: 31467190.

October 15, 2019

Katharine Lu Yang (Koralov)

Teng F, Goc J, Zhou L, Chu C, Shah MA, Eberl G, Sonnenberg GF. A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Sci Immunol. 2019 Oct 4;4(40). pii: eaax1215. doi: 10.1126/sciimmunol.aax1215. PubMed PMID: 31586011.

Henry Nguyen (Littman)

Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 1. pii: S1074-7613(19)30376-0. doi: 10.1016/j.immuni.2019.09.005. [Epub ahead of print] PubMed PMID: 31604686.

October 8, 2019

Doua Azzouz (Silverman)

Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 Aug 28;11(507). pii: eaau9356. doi: 10.1126/scitranslmed.aau9356. PubMed PMID: 31462512; PubMed Central PMCID: PMC6758550. 

Joe Pucella (Reizis)

Graf C, Wilgenbus P, Pagel S, Pott J, Marini F, Reyda S, Kitano M, Macher-Göppinger S, Weiler H, Ruf W. Myeloid cell-synthesized coagulation factor X dampens antitumor immunity. Sci Immunol. 2019 Sep 20;4(39). pii: eaaw8405. doi: 10.1126/ sciimmunol.aaw8405. PubMed PMID: 31541031.

October 1, 2019

Shruti Naik

Johnny Bonnardel, Wouter T’Jonck, Djoere Gaublomme, Robin Browaeys, Charlotte L. Scott, Liesbet Martens, Bavo Vanneste, Sofie De Prijck, Sergei A. Nedospasov, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Wendy Toussaint, Pieter De Bleser, Inge Mannaerts, Alain Beschin, Leo A. van Grunsven, Bart N. Lambrecht, Tom Taghon, Saskia Lippens, Dirk Elewaut, Yvan Saeys, Martin Guilliams, Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche, Immunity, 2019, https://doi.org/10.1016/j.immuni.2019.08.017.

Ying-Han Chen (Cadwell)

Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, Raulet DH. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature. 2019 Sep;573(7774):434-438. doi: 10.1038/s41586-019-1553-0. Epub 2019 Sep 11. PubMed PMID: 31511694.

September 24, 2019

Patrícia d'Emery Alves Santos (Lafaille)

Rivadeneira DB, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk AV, Sampath P, Lafyatis R, Ferris RL, Sarkar SN, Thorne SH, Delgoffe GM. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019 Sep 17;51(3):548-560.e4. doi: 10.1016/j.immuni.2019.07.003. Epub 2019 Aug 27. PubMed PMID: 31471106.

September 17, 2019

Simone Dallari (Cadwell)

Wang L, Wen M, Cao X. Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 2019 Aug 16;365(6454). pii: eaav0758. doi: 10.1126/science.aav0758. Epub 2019 Jul 18. PubMed PMID: 31320558.

September 10, 2019

Ranit Kedmi (Littman)

Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 2019 Aug 22; 178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050. PubMed PMID: 31442403.

Hernandez Moura Silva (Lafaille)

Collins N, Han SJ, Enamorado M, Link VM, Huang B, Moseman EA, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y. The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction. Cell. 2019 Aug 22; 178(5):1088-1101.e15. doi: 10.1016/j.cell.2019.07.049. PubMed PMID: 31442402.

September 3, 2019

Ioanna Tiniakou (Reizis)

Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R. Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Immunity. 2019 Aug 27. pii: S1074-7613(19)30323-1. doi: 10.1016/j.immuni.2019.07.007. [Epub ahead of print] PubMed PMID: 31471108.

Yu Matsuzawa (Cadwell)

Paczulla AM, Rothfelder K, Raffel S, Konantz M, Steinbacher J, Wang H, Tandler C, Mbarga M, Schaefer T, Falcone M, Nievergall E, Dörfel D, Hanns P, Passweg JR, Lutz C, Schwaller J, Zeiser R, Blazar BR, Caligiuri MA, Dirnhofer S, Lundberg P, Kanz L, Quintanilla-Martinez L, Steinle A, Trumpp A, Salih HR, Lengerke C. Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. 2019 Aug;572(7768):254-259. doi: 10.1038/s41586-019-1410-1. Epub 2019 Jul 17. Erratum in: Nature. 2019 Aug 1; PubMed PMID: 31316209.

August 27, 2019

Axel Concepcion (Feske)

Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature. 2019 Sep;573(7772):69-74. doi: 10.1038/s41586-019-1485-8. Epub 2019 Aug 21. PubMed PMID: 31435009.

Susan Schwab

Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019 Apr 5;364(6435). pii: eaau1330. doi: 10.1126/science.aau1330. Epub 2019 Mar 14. PubMed PMID: 30872533; PubMed Central PMCID: PMC6532986.

August 13, 2019

Ken Cadwell

Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science. 2019 Aug 1. pii: eaaw6433. doi: 10.1126/science.aaw6433. [Epub ahead of print] PubMed PMID: 31371561.

Evan Patel (Littman)

Saligrama N, Zhao F, Sikora MJ, Serratelli WS, Fernandes RA, Louis DM, Yao W, Ji X, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, Davis MM. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. 2019 Aug 7. doi: 10.1038/s41586-019-1467-x. [Epub ahead of print] PubMed PMID: 31391585.

August 6, 2019

Jessica Neil (Cadwell)

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. T cell-mediated regulation of the microbiota protects against obesity. Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351. PubMed PMID: 31346040.

Hao Xu (Littman)

Nagashima H, Mahlakõiv T, Shih HY, Davis FP, Meylan F, Huang Y, Harrison OJ, Yao C, Mikami Y, Urban JF Jr, Caron KM, Belkaid Y, Kanno Y, Artis D, O'Shea JJ. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity. 2019 Jul 16. pii: S1074-7613(19)30279-1. doi: 10.1016/j.immuni.2019.06.009. [Epub ahead of print] PubMed PMID: 31353223.

July 30, 2019

Audrey Baeyens (Schwab)

Liu Q, Johnson EM, Lam RK, Wang Q, Bo Ye H, Wilson EN, Minhas PS, Liu L, Swarovski MS, Tran S, Wang J, Mehta SS, Yang X, Rabinowitz JD, Yang SS, Shamloo M, Mueller C, James ML, Andreasson KI. Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Immunol. 2019 Aug; 20(8):1023-1034. doi: 10.1038/s41590-019-0421-2. Epub 2019 Jul 1. PubMed PMID: 31263278.

Hannah Fehlner-Peach (Littman)

Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. Cell Host Microbe. 2019 Jul 10;26(1):100-113.e8. doi: 10.1016/j.chom.2019.05.003. Epub 2019 Jun 18. PubMed PMID: 31227334.

July 23, 2019

Sascha Kahlfuss (Feske)

Omenetti S, Bussi C, Metidji A, Iseppon A, Lee S, Tolaini M, Li Y, Kelly G, Chakravarty P, Shoaie S, Gutierrez MG, Stockinger B. The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells. Immunity. 2019 Jul 16; 51(1): 77-89.e6. doi: 10.1016/j.immuni.2019.05.004. Epub 2019 Jun 19. PubMed PMID: 31229354.

July 16, 2019

Ali Rashidfarrokhi (Papagiannakopoulos)

Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, Magrini E, Gianni F, Kunderfranco P, Polentarutti N, Pasqualini F, Di Marco S, Supino D, Peano C, Cananzi F, Colombo P, Pilotti S, Alomar SY, Bonavita E, Galdiero MR, Garlanda C, Mantovani A, Jaillon S. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. Cell. 2019 Jul 11;178(2):346-360.e24. doi: 10.1016/j.cell.2019.05.047. Epub 2019 Jun 27. PubMed PMID: 31257026.

Kai Mesa (Littman)

Dulken BW, Buckley MT, Navarro Negredo P, Saligrama N, Cayrol R, Leeman DS, George BM, Boutet SC, Hebestreit K, Pluvinage JV, Wyss-Coray T, Weissman IL, Vogel H, Davis MM, Brunet A. Single-cell analysis reveals T cell infiltration in old neurogenic niches. Nature. 2019 Jul;571(7764):205-210. doi: 10.1038/s41586-019-1362-5. Epub 2019 Jul 3. PubMed PMID: 31270459.

July 9, 2019

Ludovic Desvignes

Pundir P, Liu R, Vasavda C, Serhan N, Limjunyawong N, Yee R, Zhan Y, Dong X, Wu X, Zhang Y, Snyder SH, Gaudenzio N, Vidal JE, Dong X. A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity. Cell Host Microbe. 2019 Jul 10;26(1):114-122.e8. doi: 10.1016/j.chom.2019.06.003. Epub 2019 Jul 2. PubMed PMID: 31278040; PubMed Central PMCID: PMC6649664.

July 2, 2019

June-Yong Lee (Littman)

Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara SJ, Zamarin D, Walther T, Snyder AC, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman M, Kaye J, Betel D, Philip M, Schietinger A. TOX is a critical regulator of tumour-specific T cell differentiation. Nature. 2019 Jun 17. doi: 10.1038/s41586-019-1324-y. [Epub ahead of print] PubMed PMID: 31207604.

Syed Bukhari (Naik)

Camara A, Cordeiro OG, Alloush F, Sponsel J, Chypre M, Onder L, Asano K, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller CG. Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity. 2019 Jun 18; 50(6): 1467-1481.e6. doi: 10.1016/j.immuni.2019.05.008. Epub 2019 Jun 11. PubMed PMID: 31201093.

June 25, 2019

Lin Wu (Littman)

Ansaldo E, Slayden LC, Ching KL, Koch MA, Wolf NK, Plichta DR, Brown EM, Graham DB, Xavier RJ, Moon JJ, Barton GM. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science. 2019 Jun 21; 364(6446): 1179-1184. doi: 10.1126/science.aaw7479. PubMed PMID: 31221858.

Eugene Rudensky (Cadwell)

Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. CD8(+) T cells induce cachexia during chronic viral infection. Nat Immunol. 2019 Jun; 20(6):701-710. doi: 10.1038/s41590-019-0397-y. Epub 2019 May 20. PubMed PMID: 31110314; PubMed Central PMCID: PMC6531346.

June 18, 2019

Yue Xing (Naik)

Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d'Errico P, Baasch S, Amann L, Masuda T, Lösslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke CW, Grün D, Lämmermann T, Prinz M, Henneke P. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity. 2019 Jun 5. pii: S1074-7613(19)30229-8. doi: 10.1016/j.immuni.2019.05.009. [Epub ahead of print] PubMed PMID: 31201094.

Patty Martin (Cadwell)

Croft AP, Campos J, Jansen K, Turner JD, Marshall J, Attar M, Savary L, Wehmeyer C, Naylor AJ, Kemble S, Begum J, Dürholz K, Perlman H, Barone F, McGettrick HM, Fearon DT, Wei K, Raychaudhuri S, Korsunsky I, Brenner MB, Coles M, Sansom SN, Filer A, Buckley CD. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature. 2019 May 29. doi: 10.1038/s41586-019-1263-7. [Epub ahead of print] PubMed PMID: 31142839.

June 11, 2019

Oriana Perez (Reizis)

Ovcinnikovs V, Ross EM, Petersone L, Edner NM, Heuts F, Ntavli E, Kogimtzis A, Kennedy A, Wang CJ, Bennett CL, Sansom DM, Walker LSK. CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells. Sci Immunol. 2019 May 31;4(35). pii: eaaw0902. doi: 10.1126/sciimmunol.aaw0902. PubMed PMID: 31152091.

Varsha Raghavan (Littman)

Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1. Cell Host Microbe. 2019 May 8;25(5):706-718.e7. doi: 10.1016/j.chom.2019.03.012. Epub 2019 Apr 30. PubMed PMID: 31053533.

June 4, 2019

Jamil Kitoko (Lafaille)

Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, Sparwasser T, Bérard M, Cerf-Bensussan N, Eberl G. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity. 2019 May 21;50(5): 1276-1288.e5.

Jhimmy Talbot (Littman

Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature. 2019 Apr; 568(7753):541-545.)

May 28, 2019

Dhaval Dixit (Schwab)

Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019 Apr 18;177(3):541-555.e17.

Tariq Najar (Littman)

Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, Singh B, Rosenblum MD, Fuchs E. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells. Cell. 2019 May 16;177(5):1172-1186.e14.

May 21, 2019

Xiaomin Yao (Cadwell)

He M, Chaurushiya MS, Webster JD, Kummerfeld S, Reja R, Chaudhuri S, Chen YJ, Modrusan Z, Haley B, Dugger DL, Eastham-Anderson J, Lau S, Dey A, Caothien R, Roose-Girma M, Newton K, Dixit VM. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019 Apr 19;364(6437):283-285. doi: 10.1126/science.aav4902. Epub 2019 Apr 18. PubMed PMID: 31000662.

Henry Nguyen (Littman)

Saleh MM, Frisbee AL, Leslie JL, Buonomo EL, Cowardin CA, Ma JZ, Simpson ME, Scully KW, Abhyankar MM, Petri WA Jr. Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection. Cell Host Microbe. 2019 May 8;25(5):756-765.e5. doi: 10.1016/j.chom.2019.03.003. Epub 2019 Apr 16. PubMed PMID: 31003940; PubMed Central PMCID: PMC6509008.

May 14, 2019

Katharine Lu Yang (Koralov)

Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 Apr 10. pii: S1074-7613(19)30140-2. doi: 10.1016/j.immuni.2019.03.023. [Epub ahead of print] PubMed PMID: 31027995. 

Joe Pucella (Reizis)

Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019 May;569(7755):270-274. doi:10.1038/s41586-019-1170-y. Epub 2019 May 1. PubMed PMID: 31043744.

May 7, 2019

Shruti Naik

Sweere JM, Van Belleghem JD, Ishak H, Bach MS, Popescu M, Sunkari V, Kaber G, Manasherob R, Suh GA, Cao X, de Vries CR, Lam DN, Marshall PL, Birukova M, Katznelson E, Lazzareschi DV, Balaji S, Keswani SG, Hawn TR, Secor PR, Bollyky PL. Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. Science. 2019 Mar 29;363(6434). pii: eaat9691. doi: 10.1126/science.aat9691. PubMed PMID: 30923196. 

Doua Azzouz (Silverman lab)

Torres J, Hu J, Seki A, Eisele C, Nair N, Huang R, Tarassishin L, Jharap B, Cote-Daigneault J, Mao Q, Mogno I, Britton GJ, Uzzan M, Chen CL, Kornbluth A, George J, Legnani P, Maser E, Loudon H, Stone J, Dubinsky M, Faith JJ, Clemente JC, Mehandru S, Colombel JF, Peter I. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice. Gut. 2019 Apr 29. pii: gutjnl-2018-317855. doi: 10.1136/gutjnl-2018-317855. [Epub ahead of print] PubMed PMID: 31036757.

April 30, 2019

Patrícia d'Emery Alves Santos (Lafaille)

Janela B, Patel AA, Lau MC, Goh CC, Msallam R, Kong WT, Fehlings M, Hubert S, Lum J, Simoni Y, Malleret B, Zolezzi F, Chen J, Poidinger M, Satpathy AT, Briseno C, Wohn C, Malissen B, Murphy KM, Maini AA, Vanhoutte L, Guilliams M, Vial E, Hennequin L, Newell E, Ng LG, Musette P, Yona S, Hacini-Rachinel F, Ginhoux F. A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils. Immunity. 2019 Apr 16; 50(4): 1069-1083.e8. doi: 10.1016/j.immuni.2019.03.001. Epub 2019 Mar 27. PubMed PMID: 30926233.

Ying-Han Chen (Cadwell)

Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature. 2019 Mar; 567(7747): 262-266. doi: 10.1038/s41586-019-1006-9. Epub 2019 Mar 6. PubMed PMID: 30842662.

April 23, 2019

Stefan Feske

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science. 2019 Mar 29;363(6434). pii: eaau0135. doi: 10.1126/science.aau0135. PubMed PMID: 30923193.

Hernandez Moura Silva (Lafaille)

Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019 Apr 17. doi: 10.1038/s41586-019-1118-2. [Epub ahead of print] PubMed PMID: 30996346.

April 16, 2019

Ranit Kedmi (Littman)

Kurup SP, Anthony SM, Hancox LS, Vijay R, Pewe LL, Moioffer SJ, Sompallae R, Janse CJ, Khan SM, Harty JT. Monocyte-Derived CD11c(+) Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria. Cell Host Microbe. 2019 Apr 10;25(4):565-577.e6. doi: 10.1016/j.chom.2019.02.014. Epub 2019 Mar 21. PubMed PMID: 30905437; PubMed Central PMCID: PMC6459714.

Simone Dallari (Cadwell)

Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019 Mar 7; 176(6):1432-1446.e11. doi: 10.1016/j.cell.2019.01.049. Epub 2019 Feb 28. PubMed PMID: 30827685.

April 9, 2019

Ioanna Tiniakou (Reizis)

Binnewies, M., A. M. Mujal, J. L. Pollack, A. J. Combes, E. A. Hardison, K. C. Barry, J. Tsui, M. K. Ruhland, K. Kersten, M. A. Abushawish, M. Spasic, J. P. Giurintano, V. Chan, A. I. Daud, P. Ha, C. J. Ye, E. W. Roberts and M. F. Krummel "Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity." Cell. April 4, 2019

Yu Matsuzawa (Cadwell)

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30. PubMed PMID: 30700910; PubMed Central PMCID: PMC6367023.

April 2, 2019

Matt Keller

Ye L, Schnepf D, Becker J, Ebert K, Tanriver Y, Bernasconi V, Gad HH, Hartmann R, Lycke N, Staeheli P. Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nat Immunol. 2019 Mar 18. doi: 10.1038/s41590-019-0345-x. [Epub ahead of print] PubMed PMID: 30886417. 

Axel Concepcion Gonzalez

Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S. An essential role for the Zn(2+) transporter ZIP7 in B cell development. Nat Immunol. 2019 Mar; 20(3):350-361. doi: 10.1038/s41590-018-0295-8. Epub 2019 Feb 4. PubMed PMID: 30718914.

March 19, 2019

Boris Reizis

Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Quantifying in situ adaptive immune cell cognate interactions in humans. Nat Immunol. 2019 Feb 18. doi: 10.1038/s41590-019-0315-3. [Epub ahead of print] PubMed PMID: 30778242.

Carlos Aranda (Maria Lafaille)

Castro-Dopico, T., T. W. Dennison, J. R. Ferdinand, R. J. Mathews, A. Fleming, D. Clift, B. J. Stewart, C. Jing, K. Strongili, L. I. Labzin, E. J. M. Monk, K. Saeb-Parsy, C. E. Bryant, S. Clare, M. Parkes and M. R. Clatworthy "Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis." Immunity. (2019), https://doi.org/10.1016/j.immuni.2019.02.006

March 12, 2019

Susan Schwab

Postat J, Olekhnovitch R, Lemaître F, Bousso P. A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses. Immunity. 2018 Oct 16;49(4):654-665.e5. doi: 10.1016/j.immuni.2018.07.014. Epub 2018 Sep 25. PubMed PMID: 30266340.

Maria Lafaille

Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell. 2019 Feb 16. pii: S0092-8674(19)30104-7. doi: 10.1016/j.cell.2019.01.041. [Epub ahead of print] PubMed PMID: 30799037.

March 5, 2019

Ken Cadwell

Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. 2019 Feb 21;176(5):967-981.e19. doi: 10.1016/j.cell.2018.12.039. Epub 2019 Feb 7. PubMed PMID: 30739797.

Rabi Upadhyay (Littman)

Park SL, Buzzai A, Rautela J, Hor JL, Hochheiser K, Effern M, McBain N, Wagner T, Edwards J, McConville R, Wilmott JS, Scolyer RA, Tüting T, Palendira U, Gyorki D, Mueller SN, Huntington ND, Bedoui S, Hölzel M, Mackay LK, Waithman J, Gebhardt T. Tissue-resident memory CD8(+) T cells promote melanoma-immune equilibrium in skin. Nature. 2019 Jan;565(7739):366-371. doi: 10.1038/s41586-018-0812-9. Epub 2018 Dec 31. Erratum in: Nature. 2019 Feb 11; PubMed PMID: 30598548.

February 26, 2019

Jessica Neil (Cadwell)

Barnstorf I, Borsa M, Baumann N, Pallmer K, Yermanos A, Joller N, Spörri R, Welten SPM, Kräutler NJ, Oxenius A. Chronic virus infection compromises memory bystander T cell function in an IL-6/STAT1-dependent manner. J Exp Med. 2019 Feb 11. pii: jem.20181589. doi: 10.1084/jem.20181589. [Epub ahead of print] PubMed PMID: 30745322.

Hao Xu (Littman)

Kobayashi T, Voisin B, Kim DY, Kennedy EA, Jo JH, Shih HY, Truong A, Doebel T, Sakamoto K, Cui CY, Schlessinger D, Moro K, Nakae S, Horiuchi K, Zhu J, Leonard WJ, Kong HH, Nagao K. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium. Cell. 2019 Jan 25. pii: S0092-8674(18)31645-3. doi: 10.1016/j.cell.2018.12.031. [Epub ahead of print] PubMed PMID: 30712873.

February 19, 2019

Juan Lafaille

Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Priller J, Stadelmann C, Prinz M. Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature. 2019 Feb 13. doi: 10.1038/s41586-019-0924-x. [Epub ahead of print] PubMed PMID: 30760929.

Hannah Fehlner-Peach (Littman)

Wegorzewska MM, Glowacki RWP, Hsieh SA, Donermeyer DL, Hickey CA, Horvath SC, Martens EC, Stappenbeck TS, Allen PM. Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen. Sci Immunol. 2019 Feb 8;4(32). pii: eaau9079. doi: 10.1126/sciimmunol.aau9079. PubMed PMID:30737355.

February 12, 2019

Audrey Baeyens (Schwab)

Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE, Johnson E, Gabriac M, Kim MS, Lee J, Lee JE, Kim YS, Bae YC, Kim SJ, Lee KM, Na HS, Riva P, Latremoliere A, Rinaldi S, Ugolini S, Costigan M, Oh SB. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019 Jan 25. pii: S0092-8674(18)31636-2. doi: 10.1016/j.cell.2018.12.022. [Epub ahead of print] PubMed PMID: 30712871.

Sascha Kahlfuss (Feske)

Srikanth S, Woo JS, Wu B, El-Sherbiny YM, Leung J, Chupradit K, Rice L, Seo GJ, Calmettes G, Ramakrishna C, Cantin E, An DS, Sun R, Wu TT, Jung JU, Savic S, Gwack Y. The Ca(2+) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019 Feb;20(2):152-162. doi: 10.1038/s41590-018-0287-8. Epub 2019 Jan 14. PubMed PMID: 30643259; PubMed Central PMCID: PMC6340781.

February 5, 2019

Kai Mesa (Littman)

Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S. Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction. Nat Immunol. 2019 Jan;20(1):29-39. doi: 10.1038/s41590-018-0272-2. Epub 2018 Dec 11. PubMed PMID: 30538339.

Ali Rashidfarrokhi (Papagiannakopoulos)

Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12. Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11. PubMed PMID: 30552023; PubMed Central PMCID: PMC6301092.

January 29, 2019

Michelle Krogsgaard

Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 Nov 20;49(5):829-841.e6. doi: 10.1016/j.immuni.2018.09.007. Epub 2018 Oct 30. PubMed PMID: 30389415; PubMed Central PMCID: PMC6249037.

June-Yong Lee (Littman)

Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y, Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K, Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D, Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B, Roberts B, Hattori M, Xavier RJ, Atarashi K, Honda K. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. Nature. 2019 Jan;565(7741):600-605. doi: 10.1038/s41586-019-0878-z. Epub 2019 Jan 23. PubMed PMID: 30675064.

January 22, 2019

Eugene Rudensky (Cadwell lab)

Chen J, Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 Dec;564(7734):71-76. doi: 10.1038/s41586-018-0761-3. Epub 2018 Nov 28. PubMed PMID: 30487600.

Lin Wu (Littman lab)

Gu Y, Liu Y, Fu L, Zhai L, Zhu J, Han Y, Jiang Y, Zhang Y, Zhang P, Jiang Z, Zhang X, Cao X. Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG. Nat Med. 2019 Jan 14. doi: 10.1038/s41591-018-0309-y. [Epub ahead of print] PubMed PMID: 30643287.

January 15, 2019

Sean Saunders (Maria Lafaille lab)

Kim CJ, Lee CG, Jung JY, Ghosh A, Hasan SN, Hwang SM, Kang H, Lee C, Kim GC, Rudra D, Suh CH, Im SH. The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. 2018 Dec 18;49(6):1034-1048.e8. doi: 10.1016/j.immuni.2018.10.012. PubMed PMID: 30566881.

Ludovic Desvignes

Caielli S, Veiga DT, Balasubramanian P, Athale S, Domic B, Murat E, Banchereau R, Xu Z, Chandra M, Chung CH, Walters L, Baisch J, Wright T, Punaro M, Nassi L, Stewart K, Fuller J, Ucar D, Ueno H, Zhou J, Banchereau J, Pascual V. A CD4(+) T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med. 2019 Jan;25(1):75-81. doi: 10.1038/s41591-018-0254-9. Epub 2018 Nov 26. PubMed PMID: 30478422; PubMed Central PMCID: PMC6325012.

January 8, 2019

Patty Martin (Cadwell lab)

Rojas, O.L., A.-K. Pröbstel, E.A. Porfilio, A.A. Wang, M. Charabati, T. Sun, D.S.W. Lee, G. Galicia, V. Ramaglia, L.A. Ward, L.Y.T. Leung, G. Najafi, K. Khaleghi, B. Garcillán, A. Li, R. Besla, I. Naouar, E.Y. Cao, P. Chiaranunt, K. Burrows, H.G. Robinson, J.R. Allanach, J. Yam, H. Luck, D.J. Campbell, D. Allman, D.G. Brooks, M. Tomura, R. Baumann, S.S. Zamvil, A. Bar-Or, M.S. Horwitz, D.A. Winer, A. Mortha, F. Mackay, A. Prat, L.C. Osborne, C. Robbins, S.E. Baranzini, and J.L. Gommerman, Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell, 2019.

Dan Littman

Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature. 2019 Jan 2. doi: 10.1038/s41586-018-0824-5. [Epub ahead of print] PubMed PMID: 30602786.