Yuelin Song

PhD, Massachusetts Institute of Technology, 2020

In my PhD, I studied dynamics of locus-specific DNA methylation in single cell and allelic resolution in mouse embryonic stem cells using genetically engineered reporters. Using similar approaches, I also generated new reporter epialleles to study how locus specific DNA methylation is regulated by environmental signals, such as methyl nutrients in diet.

In the Littman Lab, I will be studying how environmental signals regulate T cell differentiation in normal physiology and diseases using novel genetically engineered mouse models and functional genomic approaches.

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Publications:

  1. Song, Y.L., van den Berg, P.R., Markoulaki, S., Soldner, F., Dall'Agnese, A., Henninger, J.E., Drotar, J., Rosenau, N., Cohen, M.A., Young, R.A., et al. (2019). Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Mol Cell 75, 905.

  2. Stelzer, Y., Wu, H., Song, Y.L., Shivalila, C.S., Markoulaki, S., and Jaenisch, R. (2016). Parent-of-Origin DNA Methylation Dynamics during Mouse Development. Cell Reports 16, 3167-3180.